metabolic activation

metabolic activation

The chemical conversion of a relatively benign substance into a more hazardous one by normal biochemical processes in cells and tissues.
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Metabolic activation is relevant to these two common endocrine activities (Jacobs et al.
This is partially because of inefficiency of P450 enzymes in cell cultures for metabolic activation (Ji et al.
Five or more concentrations of the substance are usually tested and include negative (vehicle) and positive controls with and without metabolic activation.
studying physiological function, potential undesirable effects, tissue distribution, and cross-species comparison); in vitro genetic toxicity screening [Ames test (screening version); with and without metabolic activation to detect base pair and frame shit mutations, and micronucleus test (screening version); with and without metabolic activation to detect chromosomal breaks and aneuploidy].
The objective of this study was to examine the features of the mushrooms by light microscope and to evaluate the toxicity of two selected wild mushrooms by Ames test in the presence and absence of metabolic activation by using TA98 and TA100 of Salmonella typhimurium bacterial strains.
Inhibitors of testosterone biosynthetic and metabolic activation enzymes.
Metabolic activation was induced by using an S-9 mixture containing the liver homogenate from male Wistar rats that had been injected intraperitoneally with 500 mg/kg bw Aroclor 1254 and sacrificed 5 days afterwards.
In addition, Charles River will also offer BlueScreen HC with metabolic activation for the detection of pro-genotoxins.
To anticipate hazardous in vivo metabolism that might affect the fate of novel pharmaceuticals, the ICH battery of in vitro genotoxicity tests requires that all compounds are tested with and without a metabolic activation system.
The toxicity of naphthalene depends on metabolic activation, and reactive metabolite binding depends on tissue and site susceptibility.
The natural history of knee osteoarthritis often is a process of punctuated equilibrium, with periods of metabolic activation and progression, interspersed with periods of relative nonprogression and metabolic dormancy.