meta-analysis


Also found in: Dictionary, Encyclopedia, Wikipedia.

meta-analysis

 [met″ah-ah-nal´ĭ-sis]
any systematic method that uses statistical analysis to integrate the data from a number of independent studies.

meta-analysis

/meta-anal·y·sis/ (met″ah-ah-nal´ĭ-sis) a systematic method that takes data from a number of independent studies and integrates them using statistical analysis.

meta-analysis

a systematic method of evaluating statistical data based on results of several independent studies of the same problem.

meta analysis

A method that uses statistical techniques to combine results from different studies and obtain a quantitative estimate of the overall effect of a particular intervention or variable on a defined outcome—i.e., it is a statistical process for pooling data from many clinical trials to glean a clear answer. Meta-analysis produces a stronger conclusion than can be provided by any individual study.

Cons
Bias, potential for analytical sloppiness, lack of understanding of basic issues, failure to consider major covariates, and overstating the strengths and precision of the results.

meta-analysis

Data synthesis, quantitative overview Data analysis A systematic method that uses statistical techniques for combining results from different studies to obtain a quantitative estimate of the overall effect of a particular intervention or variable on a defined outcome; MA produces a stronger conclusion than can be provided by any individual study. See Cochran Collaboration, Cumulative meta-analysis.

meta-analysis

An attempt to improve the reliability of the findings of medical research by combining and analyzing the results of all discoverable trials on the same subject. In crude terms the advantages are obvious: trials that find against a hypothesis will cancel out the effect of those that find for it. Pooling of raw data is not, however, without statistical hazard and it has become apparent that meta-analysis can introduce its own sources of inaccuracy. The method is currently undergoing refinement.

meta-analysis

post-hoc statistical or trends analysis of data; i.e. analyisis of aggregated data from disparate experiments with similar research protocols
References in periodicals archive ?
Meta-analysis of subgroups showed a significant reduction in systolic BP in hypertensive (-4.
We summarized the overall meta-analysis of bladder cancer patients with the BTA stat test (Table 2).
Although the current study was open to research conducted from any large-scale datasets, only research investigating NLTS2 provided both the desired combination of study variables and sufficient statistical information needed for a meta-analysis.
Using random effects meta-analysis, a statistically significant decrease in cataracts with statins was observed.
Five case-control studies, eight cohort studies, and two randomized controlled trials with a total of nearly 14,000 CRC cases in 841,000 diabetes patients were included in the meta-analysis.
No beneficial effect on prostate cancer incidence was found for metformin intake in the meta-analysis.
The key risk factors for breast cancer that emerged from the meta-analysis were adiposity and lack of physical activity.
In the context of the Volume 98 Monographs meeting, the Working Group performed a meta-analysis and concluded that there was sufficient evidence for the carcinogenicity of exposures as a painter (IARC 2010).
And in a separate report published in the same journal, another group of researchers found in a meta-analysis of 159 studies that evaluated rapid influenza diagnostic tests (RIDTs) that these tests have high specificity for positively identifying a patient infected with influenza but low sensitivity, which means that a negative test result cannot reliably rule out influenza infection (Ann.
The second meta-analysis was conducted to help doctors to an evidence-based advice to parents on best possible treatment for infant colic.
Adherence to a vegetarian diet and diabetes risk: a systematic review and meta-analysis of observational studies.