met-enkephalin


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met-enkephalin

 [met″en-kef´ah-lin]
see enkephalin.

POMC

A gene on chromosome 2p23 that encodes proopiomelanocortin, the melanocortin family of hormones, which include alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins bind to the melanocortin receptors, a group of five G protein-coupled receptors (MC1R to MC5R) which are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

Molecular pathology
Defects of POMC are associated with susceptibility to obesity and proopiomelanocortin deficiency.

met-enkephalin

methionine enkephalin; abbreviated Met-ENK.
References in periodicals archive ?
While the cold effect in part may be mediated by IL-4 and its receptor IL-4Ra in the adipocyte precursors, in mature adipose cells a reduction in the IL4Ra is observed and probably this effect may include diverse mediators, including IL-33 and Met-enkephalin [47, 48].
Met-enkephalin is one of the simplest endogenous opioid peptides within the enkephaline family.
Our most advanced clinical program involves immunotherapy with met-enkephalin (MENK) and/or opioid growth factor (OGF), which have been shown to stimulate the immune system even in patients with advanced cancer.
In addition, the met-enkephalin produced appears to bind to cancer cell receptors, resulting in apoptosis.
Pain threshold changes in rats following central injection of beta-endorphin, Met-enkephalin, vasopressin or oxytocin antisera.
Benzodiazepine receptor binding following chronic treatment with naloxone, morphine and met-enkephalin in normal rats.
1] Additionally, immunohistochemical reactivity for a wide array of endocrine products has been variously described in GPs,[1] for example, pancreatic polypeptide, calcitonin, cholecystokinin, somatostatin, gastrin, leu-enkephalin, met-enkephalin, serotonin, substance P, and vasoactive intestinal peptide.
Regulation of neurohormone release in the fiddler crab, Uca pugilator: Effects of gammaaminobutyric acid, octopamine, met-enkephalin and beta-endorphin.
This is because in the case of neuropeptide hormones such as met-enkephalin and leu-enkephalin (precursor is proenkephalin); increased expression levels may pose a significant physiological challenge.
THE EFFECT OF MET-ENKEPHALIN AND RELATED PEPTIDES ON 1NTERLEUKIN-2 (IL-2) PRODUCTION