Another molecule, zinc mesoporphyrin
(a synthetic heme analogue with a central zinc of the mesoporphyin macrocycle) causes a dramatic downregulation of the NS5A protein by enhancing its polyubiquitination and proteasome-dependent degradation.
On each plate, two lanes were reserved for porphyrin methyl ester calibrators (equal amounts of uroporphyrin, heptacarboxylic porphyrin, hexacarboxylic porphyrin, pentacarboxylic porphyrin, coproporphyrin, and mesoporphyrin
methyl esters; Porphyrin Products).
Clinical efficacy studies in humans have been performed only with tin proto- and mesoporphyrin
because their potencies relative to ZnPP were greater (78).
Mixed calibrators of free porphyrins (uroporphyrin I, heptacarboxylic porphyrin I, hexacarboxylic porphyrin I, pentacarboxylic porphyrin I, coproporphyrin I, and mesoporphyrin
IX), deuteroporphyrin, i-urobilin, and stercobilin were purchased from Porphyrin Products.