Because mesoblastic nephromas may extensively involve the renal sinus, careful surgical and pathologic examination of the medial aspect of the nephrectomy and its margins are of paramount importance.
Based on histology, mesoblastic nephroma is classified into classic and cellular types.
The differential diagnosis for mesoblastic nephroma includes Wilms tumor, clear cell sarcoma, rhabdoid tumor, and metanephric stromal tumor.
Adult mesoblastic nephromas have also been described, which histologically look like classic mesoblastic nephromas and stain positively for smooth muscle markers.
Most mesoblastic nephromas have a favorable outcome and are treated with nephrectomy alone.