Jones and Rayner  reviewed patients referred for evaluation of kidney disease and/or hypertension who had been abusing methamphetamines and whose mean age was just 29 years, and concluded that methamphetamine use is associated with severe hypertension, half of the subjects fulfilling criteria for malignant hypertension and mesangiocapillary
glomerulonephritis that rapidly evolves to end-stage renal disease.
Eden O'Shea-Price from Prestatyn had to stop eating processed foods and limit her salt and dairy intake, after she was diagnosed with a chronic condition called Mesangiocapillary
Renal manifestations are mainly associated with two parasites: (i) Plasmodium malariae, which usually gives rise to an immune-complex mediated mesangiocapillary
glomerulonephritis (GN) several weeks after the onset of symptoms; and (ii) Plasmodium falciparum, which can cause different types of renal alterations, ranging from asymptomatic disorders to acute renal failure (1-2).
This entity includes 3 subtypes: type I MPGN, with subendothelial deposits, classic-type mesangiocapillary
glomerulonephritis; type II MPGN, with dense deposits in the GBMs; and type III MPGN, with mixed membranous and proliferative glomerulonephritis.
3) Low complement levels have been reported with the mesangiocapillary
form of glomerulonephritis.
Primary diagnosis was chronic interstitial nephropathy (n = 4), diabetic glomerulopathy (n = 3), polycystic kidney disease (n = 3), nephrosclerosis (n = 3), focal segmental glomerulosclerosis (n = 2), IgA nephropathy (n = 3), amyloidosis (n = 2), vascular nephropathy (n = 1), Goodpasture syndrome (n = 1), systemic lupus erythematosus (n = 1), uric acid nephropathy (n = 1), membranous glomerulonephritis (n = 1), mesangiocapillary
glomerulonephritis (n = 1), and unknown (n = 4).
Hypertension, end-stage renal disease and mesangiocapillary
glomerulonephritis in methamphetamine users.
Thus, class V (membranous amyloid deposition) is scored more severely that class IV (diffuse mesangiocapillary
amyloid deposition), the most pejorative class of renal amyloidosis, (3) except for class VI.
Histopathologic observations include features of mesangiocapillary
glomerular, and subendothelial immune complex deposits containing IgG, C3, and malarial antigens.
beta]-globin sequences, genome-equivalents/mmol Cr Case Prebiopsy 2 h post biopsy 1 day post biops Clinical information B1 257 242 12 214 19 849 IgA nephropathy B2 55 899 122 199 275 482 Proteinuria, histologically normal B3 102 103 621 380 6739 Membranous nephropathy B4 49 533 33 073 3538 Lupus nephritis B5 75 064 296 302 450 234 IgA nephropathy B6 287 436 31 201 147 845 Mesangiocapillary
glomerulonephritis type III
glomerulonephritis (MCGN) type 1 was found in 14 biopsy cases (58.
34,35) Recently, distribution of glomerular amyloid deposits was classified according to 6 different patterns: mesangial segmental type, mesangial nodular type, diffuse endomembranous type, mesangiocapillary
or mixed type, predominant extramembranous or perimembranous type, and hilar type.