Membranoproliferative glomerulonephritis (MPGN) is characterized by profound hypocomplementemia, mesangial cell
proliferation, mesangial interposition, and the deposition of immunoglobulins and complements in the peripheral portion of the nodules (fringe) formed by merging of glomerular capillaries.
To the Editor: In 2003, two cDNA strands were identified in a human mesangial cell
line during experimental screening for genes upregulated by angiotensin II (1).
Involvement of gelsolin in cadmium-induced disruption of the mesangial cell
Angiotensin II, the main effector of this pathway and a potent vasoconstrictor, causes glomerular hyperfiltration, mesangial cell
proliferation, ROS generation and expansion of ECM, leading to tissue fibrosis.
Both the endothelial cell and mesangial cell
have angiotensin I receptors; by antagonizing or blocking these receptors, we can prevent the excessive remodeling within the glomerulus and its mesangium, just as we have done in the myocardium and the arterial vessel wall.
officinalis--loganin and morroniside--in diabetic mice and renal mesangial cell
cultures exposed to advanced glycation end products (Xu et al.
Primary pulmonary squamous cell carcinoma associated with elevated IL-6, leukocytosis, hypercalcemia, phagocytosis, reactive lymphadenopathy and glomerular mesangial cell
proliferation via the production of PTH-rP and G-CSF.
The characteristic of histological renal lesion of IgA-N is a tumour of mesangial cell
Dietary fish oil supplementation has been shown to reduce progression of renal disease among patients with IgA nephropathy (22) and to suppress mesangial cell
activation and proliferation in animal models (23).
This protein, called Angrem52 (for angiotensin II-induced, renal mesangial cell
gene 52), displays 53% amino acid identity and 73% amino acid similarity over 337 amino acids (aa) to the Nipah virus matrix protein (data not shown).
CuraGen's CR002 is a fully human monoclonal antibody that specifically recognizes and blocks the active form of PDGF-D, a naturally occurring protein and potent stimulator of mesangial cell
growth, which is an underlying cause of glomerulonephritis.
Attenuation of mouse mesangial cell
contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase.