meprobamate


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meprobamate

 [mĕ-pro´bah-māt, mep″ro-bam´āt]
an antianxiety agent and skeletal muscle relaxant; administered orally.

me·pro·ba·mate

(mĕ-prō'bă-māt mep'brō-bam'āt), Avoid the misspelling/mispronunciation meprobromate.
An oral anxiolytic with potential for dependency and addiction.

meprobamate

/me·pro·ba·mate/ (mĕ-pro´bah-māt) (mep″ro-bam´āt) a carbamate derivative with tranquilizing and muscle relaxant actions.

mep·ro·bam·ate

(mĕp′rō-băm′āt′, mĕ-prō′bə-)
n.
A carbamate derivative used as a sedative and a muscle relaxant.

meprobamate

[miprō′bəmāt]
an antianxiety agent.
indications It is prescribed in treatment of anxiety and tension.
contraindications Intermittent porphyria, CNS depression, narrow-angle glaucoma, pregnancy, or known hypersensitivity to this drug or to the chemically related drug carisoprodol prohibits its use.
adverse effects Among the most serious adverse effects are exacerbation of intermittent porphyria, augmentation of effects of other central nervous system depressants, and various allergic reactions. Drowsiness and ataxia commonly occur.

meprobamate

A potentially addicting agent that blocks spinal interneurons, which has anticonvulsant, anxiolytic, muscle-relaxing, sedative, hypnotic and tranquilising properties.

Adverse effects
Hypotension, depression of brainstem activity, coma, death.
 
Metabolism
Liver; excreted in urine, stool.

Therapeutic range
5–30 µg/mL.
 
Toxic range
> 60 µg/mL.
 
Specimen
Serum.
 
Method
TLC, GC, colorimetry.

meprobamate

Pharmacology A potentially addicting agent with anticonvulsant, anxiolytic, muscle relaxing, sedative, hypnotic, tranquilizing properties that blocks spinal interneurons, depressing brainstem functions, coma, death; may cause hypotension Metabolism Liver; excreted in urine, stool. See Therapeutic drug monitoring.

me·pro·ba·mate

(mĕ-prō'bă-māt) Avoid the misspelling/mispronunciation meprobromate.
An oral anxiolytic with potential for dependency and addiction.

meprobamate

A mildly tranquillizing carbamate drug with muscle-relaxant properties used in combination with painkilling drugs to treat muscle and joint pain. A brand name is Equagesic.

me·pro·ba·mate

(mĕ-prō'bă-māt)
Oral anxiolytic with potential for dependency and addiction.

meprobamate

(məprō´bamāt´),
n brand names: Equanil, Miltown, Probate, Trancot;
drug class: sedative-hypnotic, anxiolytic (Controlled Substance Schedule IV);
action: nonspecific central nervous system depressant; acts in thalamus, limbic system, and spinal cord;
use: anxiety disorders.

meprobamate

a tranquilizer and skeletal muscle relaxant.
References in periodicals archive ?
Evaluation of the first immunoassay forthe semi-quantitative measurement of meprobamate in human whole blood or plasma using biochip array technology.
The list of potentially inappropriate drugs included propoxyphene, indomethacin, pentazocine, methocarbamol, carisoprodol, oxybutynin, chlorzoxazone, metaxalone, cyclobenzaprine, flurazepam, amitriptyline, doxepin, meprobamate, lorazepam, oxazepam, alprazolam, temazepam, zolpidem, triazolam, chlordiazepoxide, diazepam, hydroxyzine, promethazine, all barbiturates (except phenobarbital), and meperidine.
SOMA is contraindicated in patients with a history of acute intermittent porphyria or a hypersensitivity reaction to a carbamate such as meprobamate.
Hormones: prednisone, prednisolone, progesterone, testosterone and cortisol -- Antibiotics: ciprofloxacin, used to prevent certain infections caused by bacteria, as well as sulfamethoxazole and trimethoprim, which are used to treat a wide variety of bacterial infections including pneumonia, and urinary tract and intestinal infections -- Antidepressants: fluoxetine, prescribed to treat a variety of conditions, including depression and other mental/mood disorders -- Anti-anxiety medication: meprobamate, a treatment used to relieve nervousness or tension that exceeds stress of everyday life -- Painkillers: ibuprofen and naproxen
Acetaminophen Clofibric Acid Estradiol Prednisone Amoxicillin Codeine Estrone Roxithromycin Azithromycin Cotinine Fluoxetine Sulfamethoxazole Caffeine Dehydronifedipine Ibuprofen Sulfathiozole Carbadox Diclofenac Meprobamate Tetracycline Carbamazepine Diphenhydramine Naproxen Tylosin Phenytoin Virginiamycin
Nicotine, acetaminophen, and meprobamate are lost during the acid elution wash of TP.
Nicotine, meprobamate, and acetaminophen, seen routinely on TL-A, were often not detected on the TP screen for basic drugs.
Among the drugs described as "dangerous or inappropriate" in the study were the tranquilizers and sleeping aids Diazepam (Valium); Chlordiazepoxide (Librium, Librax); Flurazepam (Dalmane); Meprobamate (Miltown, Deprol, Equagesic, Equanil); Pentobarbitol (Nembutal); Secobarbitol (Seconal); and the arthritis drug Indomethacin (Indocin).
8 Human fibrinogen 100 Maprotiline 10 Human [gamma]- globulin 1000 Melitracen 8 Human hemoglobin 10 Meprobamate 80 Human plasmin 100 Metamizole 100 Human plasminogen 100 Metformin 340 Human transferrin 100 Mianserin 12 Poly(D-lysine) 100 Midazolam 20 Soybean inhibitor 100 Moclobemide 4 Trypsin 100
Barbiturates, meprobamate, glutethimide, and other nonbarbiturate sedatives were detected or ruled out by use of mercuric sulfate dip (neutral/weak acid extract) on plate 1A.
5 g of diphenylcarbazone in 1 L of methylene chloride:20 g/L mercuric chloride in ethanol for barbiturates and meprobamate identification; 3.