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meprobamate

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meprobamate /me·pro·ba·mate/ (mĕ-pro´bah-māt) (mep″ro-bam´āt) a carbamate derivative with tranquilizing and muscle relaxant actions.
mep·ro·bam·ate (mpr-bmt, m-prb-)
n.
A carbamate derivative used as a sedative and a muscle relaxant.

meprobamate
[miprō′bəmāt]
an antianxiety agent.
indications It is prescribed in treatment of anxiety and tension.
contraindications Intermittent porphyria, CNS depression, narrow-angle glaucoma, pregnancy, or known hypersensitivity to this drug or to the chemically related drug carisoprodol prohibits its use.
adverse effects Among the most serious adverse effects are exacerbation of intermittent porphyria, augmentation of effects of other central nervous system depressants, and various allergic reactions. Drowsiness and ataxia commonly occur.

meprobamate
meprobamate A potentially addicting agent that blocks spinal interneurons, which has anticonvulsant, anxiolytic, muscle-relaxing, sedative, hypnotic and tranquilising properties.

Adverse effects
Hypotension, depression of brainstem activity, coma, death.
 
Metabolism
Liver; excreted in urine, stool.

Therapeutic range
5–30 µg/mL.
 
Toxic range
> 60 µg/mL.
 
Specimen
Serum.
 
Method
TLC, GC, colorimetry.

meprobamate [mĕ-pro´bah-māt, mep″ro-bam´āt]
an antianxiety agent and skeletal muscle relaxant; administered orally.

meprobamate
(mprō´bamāt´),
n brand names: Equanil, Miltown, Probate, Trancot;
drug class: sedative-hypnotic, anxiolytic (Controlled Substance Schedule IV);
action: nonspecific central nervous system depressant; acts in thalamus, limbic system, and spinal cord;
use: anxiety disorders.

meprobamate
a tranquilizer and skeletal muscle relaxant.

meprobamate
Pharmacology A potentially addicting agent with anticonvulsant, anxiolytic, muscle relaxing, sedative, hypnotic, tranquilizing properties that blocks spinal interneurons, depressing brainstem functions, coma, death; may cause hypotension Metabolism Liver; excreted in urine, stool. See Therapeutic drug monitoring.

me·pro·ba·mate (mĕ-prō'bă-māt mep'brō-bam'āt), Avoid the misspelling/mispronunciation meprobromate.
An oral anxiolytic with potential for dependency and addiction.

me·pro·ba·mate (mĕ-prō'bă-māt) Avoid the misspelling/mispronunciation meprobromate.
An oral anxiolytic with potential for dependency and addiction.

me·pro·ba·mate (mĕ-prō'bă-māt)
Oral anxiolytic with potential for dependency and addiction.


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Pesce) * Evaluating the Relationship Between Carisprodol Concentrations and Meprobamate Formation and Inter-Subject and Intra-Subject Variability in Urinary Excretion of Pain Patients (First author: Stephanie A.
23), (24) A recent evaluation of a biochip-based immunoassay for the measurement of the anxiolytic agent meprobamate in whole blood or plasma reports specificity of 100%, sensitivity of 97.
When these drugs, including the tranquilizers chlorpromazine (Thorazine) and meprobamate (Miltown), gained FDA approval in the 1950s, psychiatry headed onto a new path: a biological and, unfortunately, pharmaceutical track for subduing mental symptoms.
 
 
 
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