meprobamate


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meprobamate

 [mĕ-pro´bah-māt, mep″ro-bam´āt]
an antianxiety agent and skeletal muscle relaxant; administered orally.

me·pro·ba·mate

(mĕ-prō'bă-māt mep'brō-bam'āt), Avoid the misspelling/mispronunciation meprobromate.
An oral anxiolytic with potential for dependency and addiction.

meprobamate

/me·pro·ba·mate/ (mĕ-pro´bah-māt) (mep″ro-bam´āt) a carbamate derivative with tranquilizing and muscle relaxant actions.

meprobamate

(mĕp′rō-băm′āt′, mĕ-prō′bə-)
n.
A bitter white powder, C9H18N2O4, used as a tranquilizer, muscle relaxant, and anticonvulsant.

meprobamate

[miprō′bəmāt]
an antianxiety agent.
indications It is prescribed in treatment of anxiety and tension.
contraindications Intermittent porphyria, CNS depression, narrow-angle glaucoma, pregnancy, or known hypersensitivity to this drug or to the chemically related drug carisoprodol prohibits its use.
adverse effects Among the most serious adverse effects are exacerbation of intermittent porphyria, augmentation of effects of other central nervous system depressants, and various allergic reactions. Drowsiness and ataxia commonly occur.

meprobamate

A potentially addicting agent that blocks spinal interneurons, which has anticonvulsant, anxiolytic, muscle-relaxing, sedative, hypnotic and tranquilising properties.

Adverse effects
Hypotension, depression of brainstem activity, coma, death.
 
Metabolism
Liver; excreted in urine, stool.

Therapeutic range
5–30 µg/mL.
 
Toxic range
> 60 µg/mL.
 
Specimen
Serum.
 
Method
TLC, GC, colorimetry.

meprobamate

Pharmacology A potentially addicting agent with anticonvulsant, anxiolytic, muscle relaxing, sedative, hypnotic, tranquilizing properties that blocks spinal interneurons, depressing brainstem functions, coma, death; may cause hypotension Metabolism Liver; excreted in urine, stool. See Therapeutic drug monitoring.

me·pro·ba·mate

(mĕ-prō'bă-māt) Avoid the misspelling/mispronunciation meprobromate.
An oral anxiolytic with potential for dependency and addiction.

meprobamate

A mildly tranquillizing carbamate drug with muscle-relaxant properties used in combination with painkilling drugs to treat muscle and joint pain. A brand name is Equagesic.

me·pro·ba·mate

(mĕ-prō'bă-māt)
Oral anxiolytic with potential for dependency and addiction.

meprobamate

(məprō´bamāt´),
n brand names: Equanil, Miltown, Probate, Trancot;
drug class: sedative-hypnotic, anxiolytic (Controlled Substance Schedule IV);
action: nonspecific central nervous system depressant; acts in thalamus, limbic system, and spinal cord;
use: anxiety disorders.

meprobamate

a tranquilizer and skeletal muscle relaxant.
References in periodicals archive ?
From 2000 through 2010, reimbursement volume for these tests increased from approximately 11-fold for ethanol to approximately 1500-fold for meprobamate.
I moved to Maui, Hawaii, in July 1980 and continued to drink burgundy and take meprobamate until 1983, when I checked myself into Scripps Memorial Hospital in La Jolla, Calif.
In May, the California Horse Racing Board revealed that a filly named Phone Love tested positive for the sedative meprobamate following a Dec.
Drewes has found plenty of chemicals in treated wastewater--an antibiotic, a chemical used in perfume production, the muscle relaxant drug carisoprodol, and its metabolite meprobamate, among others.
Electomyographic comparison of single doses of exercise and meprobamate as to effects of muscular relaxation.
Hammargren prescribed quaaludes, valium, elavil, triavil, meprobamate, chloral hydrate, phenobarbitol, seconal, and talwin to combat her anxiety.
Pentobarbital (a barbiturate), meprobamate (a tranquilizer sold as Equanil and Miltown) and phensuximide (an anticonvulsant) are still measurable in that groundwater plume.
Her cache of Librium, glossy black and green capsules, five hundred or more; Valiums in blue; Xanax all pearly white; red and gray Darvons; Ludiomils in good-morning-sunshine orange; tricolored Tuinal in red, redder, and baby blue; drab brown Triavil in the 4--10 proportion; there were pastel orange methadone diskets (just two of them ass kickers); some chalk-white meprobamate in the generic--wipe you out for sure; multicolored Dexedrine spansules; passionate purple Parnate; there were her Nembutals and the sea-green, let's-do-the-job-up-right Placidyl gel caps (Baby Dills).
Propanediols such as meprobamate (Equanil) were commonly prescribed prior to the introduction of the benzodiazepines, but today rarely are used.
As mind-altering drugs multiplied, with pioneers such as meprobamate (Miltown) and chlordiazepoxide (Librium) practically bypassed, particular chemicals in the brain were discovered that responded in varying ways to these medications.
Food and Drug Administration (the "FDA"): Imiquimod Cream, 5%, Cetirizine Hydrochloride Oral Solution, 1 mg/mL (Sugar Free, Bubble Gum), Meprobamate Tablets and Ranitidine Hydrochloride Syrup USP, 15 mg/mL.