mepivacaine hydrochloride

mepivacaine hydrochloride

amide local anaesthetic agent; rapid onset; moderate duration of action; maximum safe dose = 6mg/kg of body mass (i.e. 400mg for 70-kg adult); Table 1 and Table 2; see Table 3 and Table 4
 Agent (brand name) Maximum safe dose (70-kg adult) Dose per kg of body mass Lidocaine (Xylocaine) 200mg 3mg/kg Bupivacaine (Marcain) 150mg 2mg/kg Levo-bupivacaine (Chirocaine) 150mg 2mg/kg Mepivacaine (Scandonest) 400mg 6mg/kg Prilocaine (Citanest) 400mg 6mg/kg Ropivacaine (Naropin) 250mg 3.5mg/kg
 Mass of drug administered Amount of drugs administered in relation to proportional MSDs Percentage of combined MSD e.g. 70-kg adult Agent 1 6mL lidocaine 2% 120mg Equivalent to (120/200) × 100% = 60% of MSD lidocaine 77% Agent 2 5mL bupivacaine 0.5% 25mg Equivalent to (25/150) × 100% = 17% of MSD bupivacaine e.g. 40-kg child Agent 1 4mL lidocaine 2% 80mg Equivalent to (80/120) × 100% = 77% of MSD lidocaine 89.5% Agent 2 2mL bupivacaine 0.5% 10mg Equivalent to (10/80) × 100% = 12.5% of MSD bupivacaine Where more than one anaesthetic agent is injected in order to achieve both rapid anaesthesia and prolonged postoperative pain relief, the proportional MSD of each of the anaesthetic agents should be calculated, in order not to exceed the combined MSD.The calculation is the product of the patient's body mass, the percentage mass of the individual anaesthetic agent and the total volume used of each local anaesthetic drug.In the examples cited in this table, safe doses of anaesthesia would have been administered, as the combined doses of each anaesthetic does not exceed 100%.
 Type of local anaesthetic Onset time Offset time Lidocaine 5 minutes 30-90 minutes Bupivacaine 20 minutes 6-8 hours Prilocaine 5-10 minutes 2-4 hours Mepivacaine 5-10 minutes 2-4 hours Levo-bupivacaine 20-30 minutes 6-8 hours Ropivacaine 5-10 minutes 2-4 hours
 Local anaesthetic agent Proprietary name Principal drug interactions Effect of interaction Lidocaine Xylocaine Antiarrhythmic agentsAntibacterial agentsAntipsychoticsAntiviralsBeta-blockersDiureticsDolasetronUlcer-healing drugs Increased myocardial depressionIncreased risk of ventricular arrhythmias if lidocaine is given with quinpristin/dalfopristinIncreased risk of ventricular arrhythmias if lidocaine is given with any drug that prolongs the QT interval of the cardiac cyclePlasma concentration of lidocaine increased by amprenavir, atazanavir and lopinavirIncreased myocardial depressionIncreased risk of lidocaine toxicity when given with propranololThe action of lidocaine is antagonized by the hypokalaemia caused by acetazolamide, loop diuretics or thiazide and related diuretics (i.e. a greater dose of lidocaine would be required to achieve anaesthesia)Increased risk of ventricular arrhythmia if lidocaine is given with dolasetronPlasma concentration of lidocaine increased when given with cimetidine; risk of lidocaine toxicity increased with cimetidine Bupivacaine Marcain Levo-bupivacaine Chirocaine Beta-blockers Increased risk of bupivacaine toxicity when given with propranololIncreased risk of myocardial depression if given with other antiarrhythmic agents Prilocaine Citanest Antiarrhythmic agentsAntibacterial agents Increased risk of myocardial depression if given with antiarrhythmic agentsIncreased risk of methaemoglobinaemia if given with sulphonamide antibacterial agents Ropivacaine Naropin Antidepressants Metabolism of ropivacaine is inhibited by fluvoxamine, thereby enhancing the risk of ropivacaine toxicity Mepivacaine Scandonest Drug not listed in the British National Formulary

mepivacaine hydrochloride

a compound used as a local anesthetic.
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Boxes of 50 glass tubes to anesthetic mepivacaine hydrochloride 30mg / ml to 3%, 1.

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