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mephenytoin

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mephenytoin /me·phen·y·to·in/ (mĕ-fen´ĭ-to″in) an anticonvulsant used for the control of a variety of epileptic seizures.
mephenytoin [mef″en-ĭ´to-in]
an anticonvulsant administered orally in treatment of several types of epilepsy when the seizures are refractory to other drugs.

mephenytoin
(mfen´tō´n),
n brand name: Mesantoin;
drug class: hydantoin anticonvulsant;
action: reduces electrical discharges in motor cortex, reducing seizures;
uses: generalized tonic-clonic seizures, single or complex-partial seizures.

mephenytoin, methoin
a hydantoin anticonvulsant drug, similar to phenytoin, but more toxic.

mephenytoin
Mesantoin® A drug used to control seizures, convulsions, epilepsy; it is metabolized in liver to pharmacologically active normephenytoin, excreted in urine. See Therapeutic drug monitoring.


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Once the metabolism of dextromethorphan was established to cosegregate with that of debrisoquin and other prototype substrates of CYP2D6, it was unanimously accepted as an attractive alternative to the other phenotyping probes (15) because of its recognized safety, its worldwide availability, and its specificity to CYP2D6 since no co-inheritance between mephenytoin and dextromethorphan metabolism was found in human subjects.
For instance, CYP2A6 is responsible for the main metabolism of nicotine,[22] and CYP2C19 is responsible for mephenytoin metabolism.
 
 
 
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