meperidine


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analgesic

 [an″al-je´zik]
1. relieving pain.
2. pertaining to analgesia.
3. an agent that relieves pain without causing loss of consciousness.
narcotic analgesic opioid analgesic.
nonsteroidal antiinflammatory analgesic (NSAIA) nonsteroidal antiinflammatory drug.
opiate analgesic (opioid analgesic) any of a class of compounds that bind with a number of closely related specific receptors (opioid receptors) in the central nervous system to block the perception of pain or affect the emotional response to pain; such compounds include opium and its derivatives, as well as a number of synthetic compounds, and are used for moderate to severe pain. Chronic administration or abuse may lead to dependence.

meperidine

(mĕ-per´ĭ-dēn) an opioid analgesic, used as the hydrochloride salt as an analgesic and an anesthesia adjunct.

meperidine

(mə-pĕr′ĭ-dēn′)
n.
A synthetic opioid, C15H21NO2, used in its hydrochloride form as an analgesic and sedative. Also called pethidine.

meperidine

An IV opioid analgesic with an active metabolite, normeperidine.
 
Route
Parenteral, oral.
 
Pharmacologic effects
Potent blocker of pain messages to the brain.

Contraindications
Co-administration with MAOI antidepressants (may cause dizziness, lightheadedness, nausea); ritonavir.

T1/2
2–5 hours for relief of moderate to severe pain.
 
Therapeutic range
200–800 ng/mL, meperidine; 130–480 ng/mL, normeperidine.
 
Toxic range
> 7 mg/L.
 
Specimen
Random urine, serum.
 
Method
Urine, TLC; serum, GC.

meperidine

Demerol Pain management An IV agonist opioid analgesic, with an active metabolite, normeperidine Route Parenteral, oral Pharmacologic effects Powerful blocker of pain messages to the brain Contraindications Not coadministered with MAOI antidepressants–may cause dizziness, lightheadedness, nausea. See Opioids.

meperidine

See PETHIDINE.

meperidine

a centrally acting analgesic with spasmolytic properties equal to those of atropine. Has little hypnotic effect and relieves pain without reducing consciousness, muscular activity, coordination or responsiveness of the special senses. An addictive drug for humans. Called also pethidine.
References in periodicals archive ?
When other independent variables were added to explanatory models, the differences between E and C groups were significant for not prescribing meperidine (p = .
Meperidine is the opioid of chance for burn victims
63 Average consumption of meperidine (mg) after the operation On the day of operation 66.
An autopsy failed to show an obvious cause of death, but 2 months later a toxicology report indicated polypharmary: 14 drugs were found in his system, including codeine (at 10 times the therapeutic level), methaqualone (in a toxic amount), morphine, meperidine, ethchlorvynol, diazepam, and several barbiturates.
The infusion was stopped immediately, and meperidine was administered to treat a febrile nonhemolytic reaction.
The procedure was performed under deep sedation using propofol infusion and intermittent IV meperidine.
We evaluated claims for 11 Schedule II opioid analgesics--codeine phosphate, codeine sulfate, hydromorphone, levorphanol, meperidine, meperidine-promethazine combination, methadone, morphine, oxycodone--acetaminophen combination, oxycodone-aspirin combination, and controlled-release oxycodone.
Typically, all partial agonists/agonist-antagonists (buprenorphine, nalbuphine, pentazocine, butorphanol), as well as codeine, meperidine, and prophoxyphene, are avoided because of toxic metabolites or inability to titrate to increasing doses.
None of the patients was receiving dextromethorphan, diphenhydramine, ibuprofen, imipramine, meperidine, mesoridazine, or thioridazine--drugs known to produce false-positive results with other PCP immunoassays.
As for resulting mortality among patients 50 years or older, the frequently-prescribed narcotic meperidine hydrochloride (Demerol) was mentioned in only eight medical examiner reports -- indeed, less than one-fourth the number of aspirin-related reports.
Do not take AZILECT if you are taking meperidine as it could result in a serious reaction such as coma or death.