menadione


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menadione

 [men″ah-di´ōn] vitamin K3.
1. a synthetic fat-soluble vitamin that can be converted in the body to active vitamin K; administered orally or intramuscularly. See vitamin.
2. the basic double ring quinone structure that is the parent structure of the related compounds with vitamin K activity, which can be formed by addition of long side chain substituents.

men·a·di·one

(men'ă-dī'ōn),
The root of compounds that are 3-multiprenyl derivatives of menadione and known as the menaquinones or vitamins K2.
Synonym(s): vitamin K3

menadione

/men·a·di·one/ (men″ah-di´ōn) vitamin K3.
1. a synthetic fat-soluble vitamin that can be converted in the body to active vitamin K.
2. the basic double ring quinone structure that is the parent structure of the related compounds with vitamin K activity, which can be formed by addition of long side chain substituents.

menadione

(mĕn′ə-dī′ōn′)
n.
A synthetic vitamin K derivative that is a yellow crystalline powder, C11H8O2, used as a vitamin K supplement.

menadione

[men′ədi·ōn]
a synthetic fat-soluble provitamin that can be chemically converted in the body to active vitamin K. It is used as a source of vitamin K in the treatment of hypoprothrombinemia associated with vitamin K deficiency, as occurs in hepatic or biliary disease or malabsorption syndromes, or after administration of salicylates, anticoagulants, or certain antibiotics. It is administered orally or intramuscularly. See also vitamin K. Also called vitamin K3.

Menadione

A synthetic form of vitamin K. It is sometimes called vitamin K3.
Mentioned in: Vitamin Toxicity

men·a·di·one

(men'ă-dī'ōn)
Root of compounds that are 3-multiprenyl derivatives of menadione and known as the menaquinones or vitamins K2.
Synonym(s): vitamin K3.

menadione

a fat-soluble synthetic derivative of vitamin K used in the treatment and prevention of deficiency. Called also vitamin K3.

menadione sodium bisulfite
is soluble in water and can be given by injection for a rapid effect.
References in periodicals archive ?
Abreviations LBE lemon balm extract ROS reactive oxygen species MD menadione TBHP tert-butyl hydroperoxide NAC N-acetyl cysteine GSH glutathione D3T 3H-1,2-dithiole-3-thione [alpha]TOC [alpha]-Tocopherol AA ascorbic acid AUC area under the curve CRC colorectal cancer
There is a substantial research literature demonstrating that joint incubation with vitamin C and menadione is often selectively toxic to cancer cells.
To evaluate the effectiveness of these molecules compared with other "fingerprinting molecules" of oxidative stress, we treated human blood with increasing concentrations of t-BOOH, diamide, and menadione and verified the effect on GSSG and PSSG as well as on PCO and MDA concentrations.
The availability of one-third of the $30 million is subject to the achievement of specific milestones associated with the development of the company's Marqibo and menadione product candidates.
Menadione topical lotion is a first-in-class compound being developed as a prevention and/or treatment of skin toxicity associated with epidermal growth factor receptor inhibitors like Erbitux(R) and Tarceva(R).
Vitamin K ([phylloquinoneK 1], menadione [[kappa]3], menaquinone [[kappa]2], phylloquinone [2-Me-3 phytyl-1-4 napthoquinone] sourced from plants, menaquinone [2-M3-3-polyisoprenyl-1-4-naptoquinone] bacterial source) plays a major role in calcium metabolism, blood clotting, and sphingolipid metabolism, but is best known for its role in blood clotting.
In view of the structural similarities between NOS and P450 reductase, these have been investigated for the capacity of NOS to reduce the hypoxic cytotoxin tirapazamine, the anti-tumour agent doxorubicin, and also the redox cycling compound menadione.
Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells.
14]C]methyltetrahydrofolate as substrate and menadione as electron acceptor (9).
12] EFFECTS OF SCHISANDRIN B ENANTIOMERS ON CELLULAR GLUTATHIONE AND MENADIONE TOXICITY IN AML12 HEPATOCYTES, Chiu et al.