membranous glomerulonephritis

glomerulonephritis /glo·mer·u·lo·ne·phri·tis/ (glo-mer″u-lo-nĕ-fri´tis) nephritis with inflammation of the capillary loops in the renal glomeruli.

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acute glomerulonephritis  an acute form characterized by proteinuria, edema, hematuria, renal failure, and hypertension, sometimes preceded by tonsillitis or febrile pharyngitis.

chronic glomerulonephritis  a slowly progressive glomerulonephritis generally leading to irreversible renal failure.

diffuse glomerulonephritis  a severe form with proliferative changes in more than half the glomeruli, often with epithelial crescent formation and necrosis; often seen in advanced systemic lupus erythematosus.

IgA glomerulonephritis  IgA nephropathy; a chronic form marked by a hematuria and proteinuria and by deposits of immunoglobulin A in the mesangial areas of the renal glomeruli, with subsequent reactive hyperplasia of mesangial cells.

lobular glomerulonephritis , membranoproliferative glomerulonephritis a chronic, slowly progressive glomerulonephritis in which the glomeruli are enlarged as a result of proliferation of mesangial cells and irregular thickening of the capillary walls, which narrows the capillary lumina.

membranous glomerulonephritis  a form characterized histologically by proteinaceous deposits on the glomerular capillary basement membrane or by thickening of the membrane; clinically resembling chronic glomerulonephritis, occasionally with transient nephrotic syndrome.

mesangiocapillary glomerulonephritis  membranoproliferative g.

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membranous glomerulonephritis

n.

Glomerulonephritis characterized histologically by diffuse thickening of glomerular capillary basement membranes and clinically by an insidious onset of the nephrotic syndrome and by failure of proteinuria to disappear. Also called lipoid nephrosis.

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glomerulonephritis

a variety of nephritis characterized by inflammation of the capillary loops in the glomeruli of the kidney with secondary tubulointerstitial and vascular changes. It occurs in acute, subacute and chronic forms and may be secondary to infection or immune mechanisms.

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immune-mediated glomerulonephritis

caused by deposition of immune complexes on the glomerular basement membrane or autoantibodies against the glomerular basement membrane.

lobular glomerulonephritis

a form in which all glomeruli are affected, with accentuation of the lobulation of the glomerular tufts; it is marked by constant proteinuria and microscopic hematuria.

membranoproliferative glomerulonephritis, mesangiocapillary glomerulonephritis

a chronic, slowly progressive glomerulonephritis in which the glomeruli are enlarged as a result of proliferation of mesangial cells and irregular thickening of the capillary walls, which narrows the capillary lumina; the onset is sudden, with hematuria, proteinuria or nephrotic syndrome and a persistent reduction in serum complement levels and deposition of activated complement components in the glomerular capillaries. Occurs in Finnish-Landrace sheep and is the most common glomerulopathy seen in dogs.

membranous glomerulonephritis

diffuse and irregular thickening of the basement membrane where there is diffuse granular deposition of immunoglobulin and complement. The most common type of glomerular disease in cats.

mesangioproliferative glomerulonephritis

see membranoproliferative glomerulonephritis (above).

proliferative glomerulonephritis

glomerular changes are principally those of cellular proliferation.

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membranous

pertaining to or emanating from a membrane.

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membranous glomerulonephritis

see membranous glomerulonephritis.

membranous pneumocyte

see alveolar epithelial cells (type 1).

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membranous glomerulonephritis

Nephrology A common idiopathic nephropathy usually affecting those > age 40, caused by immune complex deposition in the capillary wall of the glomerular basement membrane; it is the most common cause of nephrotic syndrome Clinical Asymptomatic proteinuria or nephrotic syndrome; possibly, edema, weight gain, hypertension, nocturia, anorexia, GFR is near normal Urinalysis Oval fat bodies, hyaline, granular, fatty casts Risk factors HBV, malaria, malignant solid tumors, NHL, SLE, syphilis, etc, drug or substance exposure–gold, mercury, penicillamine, trimethadione, skin-lightening creams Treatment Glucocorticoids and/or immunsuppressants may be used in some Pts. See Glomerulonephritis.