memapsin 2

memapsin 2

(me-maps'in),
A transmembrane aspartic endopeptidase that is a candidate beta-secretase and a potential drug target for Alzheimer disease
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References in periodicals archive ?
Design of potent inhibitors for human brain memapsin 2 ([beta]-secretase).
Structure-based design: potent inhibition of human brain memapsin 2 ([beta]-secretase).
The substrate and subsite specificity information was used to design substrate analogs of the natural memapsin 2 substrate that can inhibit the function of memapsin 2.
Memapsin 2 works with another enzyme, gamma-secretase, to cut a longer protein called amyloid precursor protein.
The enzyme and inhibitor concept for Memapsin 2 is similar to the protease inhibitors created to fight HIV and AIDS.
Because Memapsin 2 only cuts the larger protein in a very specific place, Tang and his team were able to create a "decoy," whose chemical structure resembled the area where Memapsin 2 always cuts.
Once Memapsin 2 adheres to the decoy, the enzyme is completely disabled.