TRPM1

(redirected from melastatin 1)

TRPM1

A gene on chromosome 15q13.3 that encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels, which is expressed in melanocytes and may play a role in melanin synthesis.
 
Molecular pathology
TRPM1 mutations are associated with autosomal recessive complete congenital stationary night blindness-1C. Melastatin levels are inversely correlated with melanoma aggressiveness and thus useful prognostic markers for melanoma metastasis.