melarsoprol


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Related to melarsoprol: Nifurtimox, Suramin, Eflornithine

melarsoprol

 [mel-ahr´so-prol]
an antiprotozoal agent effective against trypanosomes.

melarsoprol

An older arsenical used to treat trypanosomiasis caused by Trypanosoma cruzi (Chagas disease) and T brucei gambiense (which causes 95% of cases of sleeping sickness).

Adverse effects
Arsenic poisoning, convulsions, loss of consciousness, rash, fever, nausea, vomiting, bloody stool; treatment-related fatalities are not uncommon. Pentamidine is the drug of choice for first-stage T brucei gambiense infection. Other agents (suramin, eflornithine and nifurtimox) are available in the US from the Centers for Disease Control and Prevention (CDC).

melarsoprol

A combination of melarsan oxide and dimercaprol used to treat TRYPANOSOMIASIS. The drug is highly effective but must be used with caution because of sometimes dangerous side effects including the JARISCH-HERXHEIMER REACTION. The drug is on the WHO official list.

melarsoprol

an antiprotozoal effective against Trypanosoma spp.
References in periodicals archive ?
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.
evansi se basa en farmacos antiprotozoarios como suramina, diaminazina aceturato, quinapiramina, melarsoprol e isometamidium (18).
Risk factors for encephalopathy and mortality during melarsoprol treatment of Trypanosoma brucei gambiense sleeping sickness.
dagger]) In frail patients, begin with 18 mg melarsoprol and progressively increase dose (3).
Because melarsoprol has a low solubility in water, it is dissolved in propylene glycol and administered intravenously.
1,3,6) The major adverse reaction caused by melarsoprol occurs in about 5-10% of treated cases and is called encephalopathic syndrome; a syndrome which is fatal for 10-70% of patients.
In many regions, for instance, first-choice therapy for late-stage human African trypanosomiasis (HAT, or sleeping sickness) is still based on melarsoprol, an arsenic-derived drug developed in the late 19th century that can lead to fatal encephalopathy in 5% of patients.
8), (9) Los farmacos que se usan en este caso son la pentamidina (4), el melarsoprol (5) y el megazol (6).
A preliminary comparative study on the efficacy of quinapyramine sulphate/chloride and melarsoprol in rats, experimentally infected with Trypanosoma evansi.
Advanced cases have been treated with melarsoprol or eflornithine.
WHO-recommended treatment with melarsoprol was started.