Researchers have found three compounds that inhibit melanogenesis
at multiple stages of the process for more profound skin-lightening effects.
Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis
x OH, and NO can be induced by UV and the accumulated ROS eventually causes wrinkle formation and melanogenesis
in skin .
The black pigment was found to be melanin and the process of melanogenesis
was explained in the ink gland of Sepia sp.
is a risk factor for oxidative DNA damage--study on cultured melanocytes and atypical nevus cells.
2004) and melanogenesis
in guinea pig skin (Horikoshi et al.
Theses for gradual loss of pigmentation include attenuation of enzymes involved in melanogenesis
, impaired DNA repair, loss of telomerase, and antioxidant mechanisms (14, 16-20).
Topics discussed include a history of melanosome research, classical and non-classical melanocytes in vertebrates, biosynthesis of melanins, inhibitors and enhancers of melanogenesis
, structures of melanins, biogenesis of melanosomes, and the physiologicla and pathological functions of melanososmes.
For both melasma and PIH, that means using treatments that decrease melanin formation, block the transfer of melanosomes, minimize inflammation, and nonselectively suppress melanogenesis
, or increase melanin removal through desquamation, she said.
In fact, several studies suggest that licorice extracts have anti-inflammatory properties, as well the ability to inhibit melanogenesis
, and block cyclooxygenase and lipoxygenase release.
Characterization of Melanogenesis
and Morphogenesis of Melanosomes by Physicochemical Properties of Melanin and Melanosomes in Malignant Melanoma.
Furthermore, several in vivo and in vitro studies have demonstrated a correlation between free radical production and increased melanogenesis