MC1R

(redirected from melanocortin 1 receptor)
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MC1R

A gene on chromosome 16q24.3 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase.

Molecular pathology
Genetic variations in MC1R are associated with variation in skin/hair/eye pigmentation type 2, and are linked to cutaneous malignant melanoma type 5.
References in periodicals archive ?
Melanocortin 1 receptor variation in the domestic dog.
Association of feather colour with constitutively active melanocortin 1 receptors in chicken.
Sequence polymorphism in the human melanocortin 1 receptor gene as an indicator of the red hair phenotype.
Loss of function mutations of the human melanocortin 1 receptor are common and are associated with red hair.
2002) and mutations in the melanocortin 1 receptor (MC1R) influence coat color phenotype (Andersson, 2003).
Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival.
Melanocortin 1 receptor variants in an Irish population.
Skin type, melanoma, and melanocortin 1 receptor variants.
We're talking about people with a variant of a gene called the melanocortin 1 receptor that leads to red hair.
The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma.
The study, titled, "Autocrine inhibitory influences of alpha-melanocyte-stimulating hormone in malignant pleural mesothelioma," showed that activation of express melanocortin 1 receptor (MC1R) by selective peptides or peptidomimetics might provide a novel strategy to reduce mesothelioma cell proliferation by taking advantage of an endogenous inhibitory circuit based on alpha-Melanocyte-Stimulating Hormone (alpha-MSH), and its receptor MC1R.
One theory is that redheads have a mutant melanocortin 1 receptor (MC1R) that interacts with endorphins that act as painkillers.