melanocortin


Also found in: Wikipedia.

melanocortin

Any of a family of peptide hormones, including adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormone (MSH), which are produced endogenously from proopiomelanocortin (POMC) in the pituitary gland or synthesised under controlled chemical reactions. Melanocortins act by binding to and activating melanocortin receptors.
References in periodicals archive ?
The study, published in Nature Neuroscience, found that melanocortin 4 receptors (MC4Rs) expressed by neurons that control the autonomic nervous system are key in regulating glucose metabolism and energy expenditure, said senior author Dr.
MSH (DTrp), that acts via the melanocortin (MC) system to reduce both arthritic joint inflammation and periodontitis.
Bremelanotide is a cyclic 7-amino-acid melanocortin peptide.
Furthermore, preliminary data indicate that the agouti-related protein (AGRP) gene controls melanin synthesis and processing of endogenous antagonist of the melanocortin system (Nadeau et al.
This hormone, melanocortin, signals to an ancient and almost universal apparatus deep in the brain called the reward circuit, which has evolved to guide animals toward resources, behaviours and environments - such as food, sex and warmth - that enhance their prospects for survival.
One theory is that redheads have a mutant melanocortin 1 receptor (MC1R) that interacts with endorphins that act as painkillers.
Melanocortin receptors, particularly the melanocortin 4 receptor gene (MC4R), play a major role in the development of both monogenic and polygenic obesity.
This receptor, or another in the melanocortin family, also apparently increases pain sensitivity.
The peptide was targeted to bind only to the melanocortin type 1 receptor, which is overly abundant in melanoma cells.
We're talking about people with a variant of a gene called the melanocortin 1 receptor that leads to red hair.
The researchers scrutinized the melanocortin 1 receptor (MCIR) gene, variants of which can yield light skin and red hair, especially in people of European descent.
Neuropathology topics include cellular prion protein signaling, triggers of senile plaque, preservation of mitochondria volume in age, the role of selenite on microglial migration, intensive remodeling of Parkinje cell spines, and activation and endocytic internalization of melanocortin 3 receptors in neuronal cells.