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melanoblast

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melanoblast /mel·a·no·blast/ (mel´ah-no-blast″) a cell that originates from the neural crest and develops into a melanocyte.
mel·a·no·blast (ml-n-blst, m-ln-)
n.
A precursor cell of a melanocyte or melanophore.

mela·no·blastic adj.

melanoblast
[mel′ənōblast′]
Etymology: Gk, melas, black, blastos, germ
an epithelial tissue cell containing black granules. It develops into a melanocyte from the neural crest and migrates to various parts of the body during the early stages of embryonic life before becoming a mature melanocyte capable of forming melanin.

melanoblast [mel´ah-no-blast″]
a cell that develops into a melanocyte.

melanoblast
a cell that develops into a melanocyte.


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It has been postulated that during early embryogenesis, melanoblasts migrate from the neural crest to various sites, including the epidermis, hair follicles, oral cavity, uvea, leptomeninges, and inner ear, which accounts for the development of primary malignant melanoma in these sites.
Coverage begins with physiology--historical and comparative perspectives, followed by contributions on the science of pigmentation, including general biology of mammalian pigmentation, extracutaneous melanocytes, regulation of melanoblast migration and differentiation, the chemistry and physical properties of melanins, aging and senescence of melanocytes, the genetics of melanoma, and the transformed phenotype of melanocytes, among other topics.
4,42) The role of the c-kit proto-oncogene that encodes the transmembrane tyrosine kinase receptor KIT/SCF-R is unclear, despite the KIT receptor involvement in melanoblast migration and differentiation toward melanocytes.
 
 
 
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