melanin-concentrating hormone


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melanin-concentrating hormone

A cyclic 19-residue orexigenic hypothalamic neuropeptide, which plays a key role in regulating feeding behaviour, mood, the sleep-wake cycle and energy balance.  It also has an autocrine role in regulating beta-cell mass dynamics and pancreatic islet cell secretion. Overexpression of MCH is associated with obesity; MCH knockout mice are underweight.
References in periodicals archive ?
Global Markets Direct's, 'Melanin-Concentrating Hormone Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1) - Pipeline Review, H1 2016', provides in depth analysis on Melanin-Concentrating Hormone Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1) targeted pipeline therapeutics.
The report provides comprehensive information on the Melanin-Concentrating Hormone Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
The report provides a snapshot of the global therapeutic landscape for Melanin-Concentrating Hormone Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1)
Vanderbilt's Roger Cone and his team demonstrated that the newly discovered protein, AgRP2, regulates expression of the prohormone genes pmch and pmchl, precursors to melanin-concentrating hormone, which has a pigment-lightening effect.
SELECTIVE HUMAN MELANIN-CONCENTRATING HORMONE RECEPTOR 1 AND MELANIN-CONCENTRATING HORMONE RECEPTOR 2 ANTAGONISTS FOR THE TREATMENT OF METABOLIC DISEASES
2]), which modulates circadian rhythm (Pickering and Niles, 1990); (iv) melanin-concentrating hormone (MCH), which is linked also to sleep disorders, as well as in the stress cascade (Chambers et al.
Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.
The mice are genetically engineered to lack melanin-concentrating hormone, or MCH, which is made in the brain and is known to stimulate feeding.
A team from the Joslin Diabetes Center and Brigham and Women's Hospital in Boston reported that the compound, called melanin-concentrating hormone (MCH), is found in higher levels in the brains of obese mice than in lean mice.
The study, led by Shinjae Chung and Olivier Civelli, discovered how the melanin-concentrating hormone works with dopamine in the brain's "pleasure centre" to create an addictive response to cocaine use.