melanin-concentrating hormone


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melanin-concentrating hormone

A cyclic 19-residue orexigenic hypothalamic neuropeptide, which plays a key role in regulating feeding behaviour, mood, the sleep-wake cycle and energy balance.  It also has an autocrine role in regulating beta-cell mass dynamics and pancreatic islet cell secretion. Overexpression of MCH is associated with obesity; MCH knockout mice are underweight.
References in periodicals archive ?
Vanderbilt's Roger Cone and his team demonstrated that the newly discovered protein, AgRP2, regulates expression of the prohormone genes pmch and pmchl, precursors to melanin-concentrating hormone, which has a pigment-lightening effect.
SELECTIVE HUMAN MELANIN-CONCENTRATING HORMONE RECEPTOR 1 AND MELANIN-CONCENTRATING HORMONE RECEPTOR 2 ANTAGONISTS FOR THE TREATMENT OF METABOLIC DISEASES
2]), which modulates circadian rhythm (Pickering and Niles, 1990); (iv) melanin-concentrating hormone (MCH), which is linked also to sleep disorders, as well as in the stress cascade (Chambers et al.
The mice are genetically engineered to lack melanin-concentrating hormone, or MCH, which is made in the brain and is known to stimulate feeding.
Last year, "Nature" carried a report from SB identifying the cell- surface receptor for melanin-concentrating hormone, a hormone involved in regulation of appetite.
A team from the Joslin Diabetes Center and Brigham and Women's Hospital in Boston reported that the compound, called melanin-concentrating hormone (MCH), is found in higher levels in the brains of obese mice than in lean mice.
The study, led by Shinjae Chung and Olivier Civelli, discovered how the melanin-concentrating hormone works with dopamine in the brain's "pleasure centre" to create an addictive response to cocaine use.
Just two months ago, Nature carried a report of another of the receptors recently identified through the genomics program at SB, that being the receptor for melanin-concentrating hormone, a hormone involved in regulation of appetite.
One receptor covered under the agreement with NeoTherapeutics binds to a chemical called MCH, or melanin-concentrating hormone, which plays an important role in the regulation of eating behavior.