There are seven pharmacologic subclasses of oral antidiabetic agents: alpha-glucosidase inhibitors, biguanides, dipeptidyl peptidase-4 inhibitors, meglitinides
, sulfonylureas, sodium-glucose cotransporter-2 inhibitors, and thiazolidinediones.
The greatest compliance was observed with alpha-glucosidase inhibitors (100%) and meglitinides
(100%); nonetheless, only 5 participants used these drugs.
During the study period, all TZDs, DPP-4s, GLP-ls, and meglitinides
were single-source, brand-only preparations.
9-11) In an analysis of 27 RCTs of noninsulin antidiabetic drugs in patients whose disease was not controlled by metformin alone, TZDs, sulfonylureas, and meglitinides
were associated with a 1.
The global diabetes drugs and devices market report estimates the market size (Revenue USD million - 2013 to 2020) for key market segments based on the drug type (insulin derivatives - short-acting, intermediate-acting, long-acting, premixed, and rapid-acting insulin; oral anti-diabetes drugs - alpha-glucosidase inhibitors, biguanides, DPP-4 inhibitors, meglitinides
, SGLT-2 inhibitors, sulphonylureas, thiazolidinediones; and non-insulin injectable anti-diabetes drugs - GLP-1 analogs), device type (diabetes monitoring and diagnostic devices - analog glucose meter, continuous glucose monitoring devices, glucose test strips, lancets and lancing devices; insulin delivery devices - insulin injectors, pens, pumps, syringes, etc.
Glipizide (Glucotrol[R]) Lyburide (Micronase[R]) Meglitinides
Repaglinide Stimulate beta cells to (Prandin[R]) release more insulin.
Currently, various classes of oral anti diabetic agents like sulphonylureas, biguanides, thiazolidin- ediones, meglitinides
Many approved fixed-dose combinations of metformin are available with other oral antidiabetic medications, including sulfonylureas, meglitinides
, thiazolidinediones (TZDs), DPP-4 inhibitors (Blonde & San Juan, 2012), and SGLT2 inhibitors.
Ibuprofen (most widely used analgesic and anti-inflammatory drug), Fenofibrate (the most common drug to lower cholesterol and triglycerides), Repaglinide (of Meglitinides
drugs group recently used for diabetes treatment), Azithromycin (effective drug for treatment of respiratory infections, uterine and middle ear), Carvedilol (a drug for the treatment of heart failure, ischemia) and Aprepitant (used to prevent nausea and vomiting that may occur within 24 hours after receiving cancer chemotherapy treatment) have been produced in laboratory scale and semi-industrial scale," Mehrdad Hamidi, a nanodrugs professor, told FNA on Saturday.
Use of sulfonylureas, meglitinides
, and alpha-glucosidase inhibitors are less common, as innovative medications are integrating to the market.
5 A Cochrane review which compared Second-generation sulphonylureas versus metformin thiazolidinediones insulin meglitinides
or incretin-based interventions showed no statistically significant effects regarding all-cause mortality as well as cardiovascular mortality.
During episodes of hypoglycemia caused by sulfonylureas or meglitinides
, laboratory results will show increases in insulin and C-peptide as well as detectable plasma concentrations of the medication.