megestrol acetate

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megestrol acetate

Apo-Megestrol (CA), Megace, Megace ES, Megace-OS (CA), Nu-Megestrol

Pharmacologic class: Hormone

Therapeutic class: Progestin, antineoplastic, appetite stimulant

Pregnancy risk category D (tablets), X (suspension)

Pregnancy risk category D (tablets), X (suspension)


Unknown. Thought to suppress growth of progestin-sensitive breast and endometrial tumors by inhibiting pituitary and adrenal function.


Oral suspension: 40 mg/ml

Oral suspension (concentrate): 625 mg/5 ml

Tablets: 20 mg, 40 mg

Indications and dosages

Breast cancer

Adults: 160 mg/day P.O. given as 40 mg P.O. q.i.d.

Endometrial cancer

Adults: 40 to 320 mg/day P.O. in divided doses

Anorexia, cachexia, or unexplained significant weight loss in AIDS patients

Adults: 800 mg (oral suspension only) P.O. daily, or 625 mg (oral suspension concentrate) P.O. daily

Off-label uses

• Endometriosis, endometrial hyperplasia
• Prostatic hypertrophy
• Contraception


• Hypersensitivity to drug or its components
• Known or suspected pregnancy (suspension only)


Use cautiously in:
• diabetes mellitus, severe hepatic disease, renal disease, cardiovascular disease, seizure disorders, cerebral hemorrhage, migraine, asthma, undiagnosed vaginal bleeding, depression
• history of thrombophlebitis
• breastfeeding.


• Give with meals if GI upset occurs.

Adverse reactions

CNS: headache, insomnia, drowsiness, asthenia, confusion, neuropathy, hyperesthesia, abnormal thinking, paresthesias, depression, seizures

CV: hypertension, chest pain, thrombophlebitis, deep vein thrombosis

EENT: amblyopia, retinal thrombosis, pharyngitis

GI: nausea, vomiting, constipation, abdominal pain, flatulence, dyspepsia, dry mouth, increased salivation, oral candidiasis

GU: breast tenderness, breakthrough bleeding, decreased libido

Hematologic: anemia, leukopenia

Hepatic: hepatomegaly

Metabolic: hyperglycemia

Musculoskeletal: carpal tunnel syndrome, back pain

Respiratory: dyspnea, cough, pneumonia, pulmonary embolism

Skin: alopecia, rash, pruritus, sweating

Other: edema, fever, weight gain, herpes infection


Drug-diagnostic tests.Lactate dehydrogenase: increased level

Patient monitoring

Watch for signs and symptoms of thromboembolic disorders.

Stay alert for visual disturbances, headache, abdominal pain, and hepatomegaly.
• Monitor glucose level in diabetic patients.

Patient teaching

• Inform patient that drug may cause back or abdominal pain, headache, nausea, vomiting, or breast tenderness.

Tell patient to immediately report pain, swelling or redness of lower legs, chest or back pain, or shortness of breath.
• Advise patient to contact prescriber if adverse effects become pronounced or if other troublesome signs or symptoms occur.
• Urge patient to use reliable contraception.

Instruct patient to immediately report suspected pregnancy.
• Caution female patient to avoid breastfeeding.
• Advise diabetic patient to monitor blood glucose level.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.

megestrol acetate

an antineoplastic progestational agent.
indications It is prescribed to treat endometrial cancer and more commonly to palliate advanced endometrial and breast cancer. It is also used to stimulate appetite and to promote weight gain in cachexia patients.
contraindication Hypersensitivity to the drug prohibits its use.
adverse effects Adverse effects include edema and breakthrough bleeding.

megestrol acetate

A synthetic progestin/progestational anti-androgen that blocks oestrogenic effects, androgen production and androgen-mediated activity, reducing serum gonadotropin and testosterone. It reduces hot flushes by 85% in menopausal women and androgen-deprived men compared to 20% in placebo group.

Megestrol acetate is used to manage weight loss and anorexia in patients with AIDs and breast, endometrial and prostate cancer. In combination with oestradiol, it maintains castrate levels of testosterone in patients with metastatic prostate cancer.

Adverse effects
Dysmenorrhoea, chest pain, depression, oedema in hands and feet, brown spots on skin, hirsutism, breast tenderness, hypertension, venous thrombosis.

megestrol acetate

Megace® Endocrinology A synthetic progestin/
progestational antiandrogen that blocks estrogenic effects, androgen production and androgen-mediated activity, ↓ serum gonadotropin and testosterone  Oncology A progestin used to manage weight loss, anorexia in Pts with AIDs, breast, endometrial, and rarely prostate CA Adverse effects Dysmenorrhea, chest pain, depression, edema in hands, feet, brown spots on skin, hirsutism, breast tenderness, HTN, venous thrombosis

megestrol acetate

(məjes´trōl as´ətāt),
n brand name: Megace;
drug class: antineoplastic (progestin);
action: affects endometrium by antiluteinizing effect;
uses: breast, endometrial cancer, renal cell cancer.

megestrol acetate

a synthetic progestational agent, commonly used for estrus control in dogs and cats and also in the treatment of behavioral abnormalities and a variety of inflammatory skin diseases, including miliary dermatitis and eosinophilic granuloma.
References in periodicals archive ?
Conclusions: Both formulations of megestrol acetate improved BMI; weight gain was significantly more rapid and substantial with the concentrated suspension.
The European clinical trial compares single-agent Irosustat to megestrol acetate (MA) in post-menopausal women with histologically confirmed hormone receptor positive endometrial cancer, presenting with recurrent or advanced disease not eligible for treatment with surgery and radiotherapy.
Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymesterone for the treatment of cancer.
In this issue of the Journal of Applied Research, Wanke and coworkers compare the effects of a concentrated formulation of megestrol acetate (Megace ES; Par Pharmaceutical, Spring Valley, NY) to conventional Megace in patients infected with HIV and losing weight on highly active antiretroviral therapy.
The chromatogram of a patient sample with suppressed plasma cortisol and confirmed to be positive for methylprednisolone and megestrol acetate is shown in Fig.
Pharmaceutical Resources' patents relating to its megestrol acetate formulation remain valid and in force.
ES (megestrol acetate) oral suspension is contraindicated in patients with a history of hypersensitivity to megestrol acetate or any component of the formulation, or in patients with known or suspected pregnancy.
The two trials (299 and 267 patients, respectively) compared the second-generation aromatase inhibitor fadrozole with megestrol acetate.
In response to requests from veterinarians, Wedgewood Pharmacy is now compounding Tiny Tabs([TM]) in Megestrol Acetate 5mg and Famciclovir 31.
Megestrol acetate suppresses plasma estrogen but has also glucocorticoid agonistic effects (15).
Megestrol Acetate Major Producer and Their Market Share
In patients experiencing 6 or more hot flashes per day at baseline who were not being treated with megestrol acetate (Megace([R])), toremifene citrate 80 mg was shown to reduce the number of hot flashes by an average 4.