megalencephaly


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megalencephaly

 [meg″ah-len-sef´ah-le]
macrencephalia; hypertrophy of the brain.

megalencephaly

(mĕg′əl-ĕn′sĕf′ə-lē) or

megaloencephaly

(mĕg′ə-lō-ĕn-)
n.
Abnormal largeness of the brain.

meg′al·en′ce·phal′ic (-ĕn′sə-făl′ĭk), meg′al·en′ce·phal′ous (-əs) adj.

megalencephaly

[meg′əlensef′əlē]
Etymology: Gk, megas + enkephalos, brain
a condition characterized by pathological parenchymal overgrowth of the brain. In some cases generalized cerebral hyperplasia is associated with mental retardation or a brain disorder, such as epilepsy. Also called macrencephaly. megalencephalic, megalencephalous, adj.

megalencephaly

A rare condition defined as a brain that weighs significantly more than the average for an infant’s age and sex, which is invariably accompanied by macrocephaly with an enlarged cranial vault due to separation of the cranial sutures.

megalencephaly

Neonatology Big-brained

megalencephaly

macrencephalia; hypertrophy of the brain.
References in periodicals archive ?
Megalencephaly is the result of a generalized increase in neuronal and glial proliferation or diminished apoptosis.
One case of Canavan's with megalencephaly, diffuse subcortical and periventricular white matter T2 hyperintensity in the bilateral fronto-parieto-occipital regions and also in the cerebellum.
This patient appears to have mixed megalencephaly with both type two and three as there is both association with neurofibromatosis-1 and involvement of cerebellum.
Leukoencepalopathy, megalencephaly, and mild clinical course: a recently individualized familial leukodystrophy: report on five new cases.
Echocardiography was normal, Magnetic Resonance Imaging (MRI) of orbits and brain showed the presence of Hemangioma in left temporal fossa and periorbital soft tissues with intraorbital extension and coloboma of left eye, hypoplastic left cerebellar hemisphere and left unilateral megalencephaly with prominent sulci/cisterns.
Pathologies like infection, metabolic disorders, ischemia, or genetic defects that cause errors in any of the stages of stem cell differentiation, neuronal migration, or cortical organization form cortical anomalies such as lissencephaly, pachygyria, schizencephaly, heterotopia, polymicrogyria, and unilateral megalencephaly.