Carica papaya leaf extract (CPLE) is shown to overexpress ALOX-12 and platelet-activating factor receptor gene which stimulates the megakaryopoiesis
Thrombocytopenia associated with TAR syndrome is believed to be related to a process of defective megakaryopoiesis
resulting from a faulty progenitor cell.
Excessive production of pro-inflammatory cytokines and acute-phase reactants can contribute to the development of megakaryopoiesis
and then small-sized platelets, and it can suppress the size of platelets (5).
Myelopoiesis and megakaryopoiesis
and cytochemical stains including myeloperoxidase, non specific esterase and Periodic Acid Schiff stain.
Moreover, genomewide association studies have found that regulation of platelet count and volume in healthy individuals may occur as a result of highly heritable traits between individuals due to single nucleotide polymorphisms (28) in several genes that regulate megakaryopoiesis
and proplatelet formation (29).
The GATA1 gene is located on the X chromosome and encodes a zinc finger transcription factor that is essential for normal erythropoiesis and megakaryopoiesis
A BM aspiration performed at 6 months of the ATG therapy showed myeloid and erythroid hyperplasia with normal megakaryopoiesis
However, according to more recent studies, these autoantibodies, directed against glycoproteins of the integrin family, also prevent formation of new platelets via inhibited megakaryopoiesis
or destruction of megakaryocytes within the bone marrow.
A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis
Normal marrow erythropoiesis and megakaryopoiesis
Thrombopoietin is a glycoprotein and a major regulator of megakaryopoiesis
and platelet production in the body.
in chronic myeloproliferative diseases: a morphometric evaluation with special emphasis on primary thrombocythemia.