medulloblastoma


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medulloblastoma

 [mĕ-dul″o-blas-to´mah]
a brain tumor composed of medulloblasts.

me·dul·lo·blas·to·ma

(med'yŭ-lō-blas-tō'mă), [MIM*155255]
`A tumor consisting of neoplastic cells that resemble the undifferentiated cells of the primitive medullary tube; medulloblastomas are usually located in the vermis of the cerebellum, and may be implanted discretely or coalescently on the surfaces of the cerebellum, brainstem, and spinal cord; they comprise approximately 3% of all intracranial neoplasms, and occur most frequently in children; the neoplastic cells are compactly arranged, rounded or ovoid, with hyperchromatic nuclei and relatively scant cytoplasm, and lie in small and poorly defined groups, or, occasionally, in a pseudorosette pattern (Homer-Wright rosette). A type of primitive neuroectodermal tumor.

medulloblastoma

[mədul′ōblastō′mə]
Etymology: L, medulla + Gk, blastos, germ, oma, tumor
a poorly differentiated malignant neoplasm composed of tightly packed cells of spongioblastic and neuroblastic lineage. The tumor usually arises in the cerebellum, occurs most frequently at 5 to 9 years of age, and affects more boys than girls. Medulloblastomas are extremely radiosensitive and grow rapidly. The prognosis is poor.
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Medulloblastoma

medulloblastoma

Primitive neuroectodermal tumor Neurology A malignant brain tumor that comprises ±14 of intracranial tumors in children and adolescents; it is most common at the midline of the cerebellum, and on the roof of 4th ventricle Clinical Presents with N&V, headache, ataxia, papilledema, nystagmus, irritability, lethargy, cranial nerve palsy, dizziness, altered vision Prognosis 2 yr-survival after relapse is 46% in those treated with salvage chemotherapy or RT, 0% in untreated Pts. See Brain tumor. Cf Glioblastoma.

me·dul·lo·blas·to·ma

(mĕ-dŭl'ō-blas-tō'mă)
A tumor consisting of neoplastic cells that resemble the undifferentiated cells of the primitive medullary tube; medulloblastomas are usually located in the vermis of the cerebellum, comprise approximately 3% of all intracranial neoplasms, and occur most frequently in children.

medulloblastoma

A malignant brain tumour, most commonly affecting children and usually occurring in the CEREBELLUM or in the nearby roof of the FOURTH VENTRICLE.

medulloblastoma

a brain tumor composed of medulloblasts.
References in periodicals archive ?
National Cancer Institute and DelMar's recent clinical and preclinical data, the Company sought to further investigate the cytotoxic activity of VAL-083 against resistant forms of pediatric medulloblastoma and pediatric high grade gliomas cell lines, in vitro.
The concept proposed is to identify different patterns of tumor-recognizing antibodies in the blood that indicate the presence/absence of medulloblastoma and differentiate between types of medulloblastoma tumors in children," said Dr.
Oncurious plans to initiate a Phase I/IIa clinical program with TB-403 for the treatment of medulloblastoma, a rare, life-threatening brain tumor that mainly affects children.
Oncurious now plans to initiate a Phase I/IIa clinical trial with TB-403 in medulloblastoma patients.
Jack has medulloblastoma, a cancerous tumour that develops in the cerebellum - part of the brain that controls balance and other motor functions.
They make up about 20% of all childhood brain tumours Medulloblastoma .
Nicole, who is also a dancer, knew the perfect recipient of the wish, a 7-year-old ballerina with the diagnosis of medulloblastoma, a form of brain cancer.
ThromboGenics NV (Euronext Brussels: THR), and co-development partner BioInvent International AB (OMXS: BINV), announce today the publication of a paper in the prestigious journal Cell, highlighting the potential of TB-403 to improve the treatment of medulloblastoma, the most common brain tumor in children.
The researchers based their study on a number of paediatric patients who had undergone conventional radiation treatment for medulloblastoma, a form of brain tumor that almost exclusively affects children, and simulated treatment plans using proton therapy techniques and newer photon therapy techniques.