medulloblastoma


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medulloblastoma

 [mĕ-dul″o-blas-to´mah]
a brain tumor composed of medulloblasts.

me·dul·lo·blas·to·ma

(med'yŭ-lō-blas-tō'mă), [MIM*155255]
`A tumor consisting of neoplastic cells that resemble the undifferentiated cells of the primitive medullary tube; medulloblastomas are usually located in the vermis of the cerebellum, and may be implanted discretely or coalescently on the surfaces of the cerebellum, brainstem, and spinal cord; they comprise approximately 3% of all intracranial neoplasms, and occur most frequently in children; the neoplastic cells are compactly arranged, rounded or ovoid, with hyperchromatic nuclei and relatively scant cytoplasm, and lie in small and poorly defined groups, or, occasionally, in a pseudorosette pattern (Homer-Wright rosette). A type of primitive neuroectodermal tumor.

medulloblastoma

[mədul′ōblastō′mə]
Etymology: L, medulla + Gk, blastos, germ, oma, tumor
a poorly differentiated malignant neoplasm composed of tightly packed cells of spongioblastic and neuroblastic lineage. The tumor usually arises in the cerebellum, occurs most frequently at 5 to 9 years of age, and affects more boys than girls. Medulloblastomas are extremely radiosensitive and grow rapidly. The prognosis is poor.
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Medulloblastoma

medulloblastoma

Primitive neuroectodermal tumor Neurology A malignant brain tumor that comprises ±14 of intracranial tumors in children and adolescents; it is most common at the midline of the cerebellum, and on the roof of 4th ventricle Clinical Presents with N&V, headache, ataxia, papilledema, nystagmus, irritability, lethargy, cranial nerve palsy, dizziness, altered vision Prognosis 2 yr-survival after relapse is 46% in those treated with salvage chemotherapy or RT, 0% in untreated Pts. See Brain tumor. Cf Glioblastoma.

me·dul·lo·blas·to·ma

(mĕ-dŭl'ō-blas-tō'mă)
A tumor consisting of neoplastic cells that resemble the undifferentiated cells of the primitive medullary tube; medulloblastomas are usually located in the vermis of the cerebellum, comprise approximately 3% of all intracranial neoplasms, and occur most frequently in children.

medulloblastoma

A malignant brain tumour, most commonly affecting children and usually occurring in the CEREBELLUM or in the nearby roof of the FOURTH VENTRICLE.

medulloblastoma

a brain tumor composed of medulloblasts.
References in periodicals archive ?
Investigators reported that inhibiting mTORC1 disrupted the Sonic Hedgehog signaling pathway and significantly extended the lives of mice with the medulloblastoma that is driven by Sonic Hedgehog signaling.
Approximately, half of all intracranial neoplasms in children are gliomas; 15% are Primitive neuroectodermal tumours including medulloblastoma, ependymoma and craniopharyngioma account for about 10% each.
The patient was diagnosed as having Gorlin-Goltz syndrome with numerous BCC, falx cerebri calcifications, maxillar and mandibular keratoodontegenic cysts, frontal bossing, highly arched palate, broad nasal bridge, hypertelorism, and a history of medulloblastoma.
Children currently undergo a combination of surgery, chemotherapy and radiotherapy to tackle medulloblastoma, but this can have debilitating side effects, including lower IQ and social problems in future.
Focally, atypical astrocytic-appearing cells were seen, but no clear morphologic evidence of residual or recurrent medulloblastoma was present.
The overexpression of CDCA7L is recognized in medulloblastoma cells, breast cancer, and hepatocellular carcinoma.
By creating a cell model of medulloblastoma from human cells rather than working with mouse cells, the researchers say they can be more confident that patients' response to the drugs identified in the screenings may be more comparable to humans, according to Eric Raabe of the Cancer Center.
3) Differential imaging considerations, including hemangioblastoma, glial tumor, primitive neuroectodermal tumor , subacute infarct, cerebellitis, or tumefactive demyelination are limited by the pathognomonic appearance on MRI, though recently there have been several case reports of infiltrating medulloblastoma mimicking Lhermitte-Duclos disease in both pediatric and adult patients.
Global Markets Direct's, 'Medulloblastoma - Pipeline Review, H1 2016', provides an overview of the Medulloblastoma pipeline landscape.
The study, published in the Lancet Oncology journal, also said the two types had similar survival rates for young people with the rare brain tumour medulloblastoma.
Kayley said: "She was diagnosed with a grade 4 medulloblastoma.
com)-- The Pediatric Brain Tumor Foundation and ABC2 (Accelerate Brain Cancer Cure) are working together to fund the development of immunosignature-based blood tests for detecting, classifying and monitoring pediatric medulloblastoma over time.