suicide substrate

(redirected from mechanism-based inhibitor)

su·i·cide sub·strate

a competitive inhibitor that is converted to an irreversible inhibitor at the active site of the enzyme.

suicide substrate

a compound that is not of itself toxic to a cell, but which resembles a normal metabolite closely enough that it undergoes metabolic transformation to a product that does inhibit a crucial enzyme, e.g. fluoroacetate. A substrate-analog that binds irreversibly to amino acids, usually the catalytic amino acid, thereby blocking the active site of the enzyme to other molecules and effectively 'killing' the enzyme.
References in periodicals archive ?
Cobicistat is Gilead's proprietary mechanism-based inhibitor of cytochrome P450 3A (CYP3A), an enzyme that metabolizes drugs in the body.
SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C virus (HCV) NS3 Protease Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Interferon alfa-2b (INF), Malcolm B.
Chapter 11: Quinone Methides and Aza-Quinone Methides as Latent Alkylating Species in the Design of Mechanism-Based Inhibitors of Serine Proteases and U-Lactamases (Michele Reboud-Ravaux and Michel Wakselman).
The group focused initially on the design of mechanism-based inhibitors, but embraced structure-based strategies and the full gamut of modern drug strategies which have enzymes as targets.