mecamylamine hydrochloride

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[mek′əmil′əmēn]

a ganglionic blocking agent (antihypertensive).

indication It is prescribed in the management of severe essential hypertension and uncomplicated malignant hypertension.

contraindications Coronary or cerebrovascular insufficiency, recent myocardial infarction, uremia, pyelonephritis, glaucoma, or known hypersensitivity to this drug prohibits its use.

adverse effects Among the most serious adverse effects are orthostatic hypotension, paralytic ileus, urinary retention, and cycloplegia. The incidence of side effects is very high because the drug reduces all autonomic activity.

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