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mecamylamine

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mecamylamine /mec·a·myl·amine/ (mek″ah-mil´ah-min) a ganglionic blocking agent used in the form of the hydrochloride salt as an antihypertensive.
mecamylamine [mek″ah-mil´ah-min]
a ganglionic blocking agent administered orally as the hydrochloride salt as an antihypertensive agent.
mecamylamine
Substance abuse A ganglion-blocker approved for HTN, possibly smoking cessation, to be used with nicotine replacement therapy–eg, gum or patches; it may ↓ tics and rage reactions in children with Tourette's syndrome. See Nicotine replacement therapy.
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The study authors were also able to undo some harmful effects of nicotine in mice to some extent by treating them with the nicotine antagonist mecamylamine, a drug that blunts the action of nicotine.
Why smoking increases heart disease, stroke risk by Asian News International
Mecamylamine was approved for treatment of hypertension in the mid-1950s but never gained broad use as an antihypertensive agent.
Drug's efficacy for treating depression 'exciting' by Jancin, Bruce / Clinical Psychiatry News
In the present study, we assessed the relative contributions of four distinct mechanisms in the developmental neurotoxicity of organophosphates by examining the ability of targeted therapies to ameliorate the effects of CPF: the combination of atropine plus mecamylamine (antagonists toward muscarinic and nicotinic acetylcholine receptors, respectively); nicotine, which both stimulates and desensitizes nicotinic receptors but also has prooxidant and antioxidant characteristics (Gitto et al.
Ameliorating the developmental neurotoxicity of chlorpyrifos: a ... by Slotkin, Theodore A.; MacKillop, Emiko A.; Ryde, Ian T.; Seidler, Frederic J. / Environmental Health Perspectives
 
 
 
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