(a nicotine antagonist) for smoking cessation.
Lancaster T, Stead LF, Mecamylamine
for smoking cessation.
modifies the pharmacokinetics and reinforcing effects of alcohol.
5 to 150 mg/d Baclofen 10 mg/d 40 to 60 mg/d Nicotine patch 7 mg/d 7 to 21 mg/d Mecamylamine
The study authors were also able to undo some harmful effects of nicotine in mice to some extent by treating them with the nicotine antagonist mecamylamine
, a drug that blunts the action of nicotine.
Intensive Intervention for Toddlers with Autism; A Pilot study of Daytrana TM in Children with Autism Co-Morbid for Attention Deficit Hyperactivity Disorder (ADHD) Symptoms; Minocycline to Treat Childhood Regressive Autism; Effectiveness of Atomoxetine in Treating Attention Deficit Hyperactivity Disorder Symptoms in Children and Adolescents with Autism; Comparing Parent-Implemented Interventions for Toddlers with Autism Spectrum Disorders and A Pilot Trial of Mecamylamine
for the Treatment of Autism are just few clinical studies and intervention regimen on autism currently funded by the United States National Institute of Health (http://clinicaltrials.
VIENNA -- Mecamylamine
, an old, rarely prescribed, truly obscure antihypertensive agent, may be favorably reincarnated as an antidepressant with a completely novel mechanism of action--and vastly greater potential use.
Furthermore, recent work on cuttlefish optic lobe slices (11) has shown that mecamylamine
hydrochloride, a nicotinic receptor antagonist, blocks excitatory postsynaptic currents, which are due to spontaneously released ACh.
Presented data from the completed Phase II clinical trial of mecamylamine
hydrochloride as an add-on therapy to citalopram hydrobromide, a treatment combination known as TRIDMAC(TM), at the 2007 Summer Meeting of the British Association for Psychopharmacology;
Induction of pulmonary cytochrome P4501A1 interactive effects of nicotine and mecamylamine
Despite this, he added, "we now only use nicotine for special problems, because we've found something better: mecamylamine
The combination of bupropion and mecamylamine
with a nicotine patch is tested for smoking cessation effectiveness in this nonrandomized, open label, uncontrolled study currently in Phase I.