mdr-1 gene

mdr-1 gene

multi-drug resistance gene; normally responsible for maintaining the blood-brain barrier to certain drugs. A deletion mutation in this gene is responsible for the sensitivity to ivermectin observed in Collie dogs and related breeds.
References in periodicals archive ?
Variation in number of copies of Plasmodium vivax mdr-1 gene in 607 isolates from residents of and travelers from France to malaria-endemic areas, South America, Asia, and Africa, 1997-2009 Variable Residents Travelers No.
KB-V-1 cells showed the overexpression of MDR-1 gene, which is known as a main reason in changing the intracellular drug concentration.
10) found that a polymorphism in exon 26 (C3435T) of the MDR-1 gene was correlated with intestinal expression and in vivo activity of P-gp.
A 252-bp fragment of the MDR-1 gene (GenBank Accession No.
The results further showed that Targretin prevented resistance and cross-resistance by suppressing the expression of the MDR-1 gene and the activity of the P-glycoprotein pump in NSCLC cells.
Therefore, genotyping of the C3435T polymorphism may provide a basis for treating patients more effectively with agents that are substrates of the MDR-1 gene product, e.
Expression of the MDR-1 gene makes cells resistant to certain chemotherapeutics by enabling cells to pump toxic chemotherapeutic drugs out before cell death occurs.
CD34+ cells (which include stem cells) will be separated from the remaining 30% and incubated with a retroviral vector containing the human MDR-1 gene in order to transfer the resistance trait to the cells.
The MDR-1 gene protects bone marrow and blood cells from the toxicity of chemotherapy by producing P-glycoprotein, a protein which pumps anticancer drugs out of cells before the drugs can cause damage.
Deisseroth's team of investigators aims to enhance chemotherapy tolerance through insertion of the MDR-1 gene into stem and progenitor bone marrow cells, which can pass the protection mechanism afforded by the gene to newly formed blood cells.