Mdr-1 gene | definition of mdr-1 gene by Medical dictionary
multi-drug resistance gene; normally responsible for maintaining the blood-brain barrier to certain drugs. A deletion mutation in this gene is responsible for the sensitivity to ivermectin observed in Collie dogs and related breeds.
References in periodicals archive
Variation in number of copies of Plasmodium vivax mdr-1 gene
in 607 isolates from residents of and travelers from France to malaria-endemic areas, South America, Asia, and Africa, 1997-2009 Variable Residents Travelers No.
High expression of MDR-1 gene
and P-glycoprotein in initial and re-biopsy specimens of relapsed B cell lymphoma.
KB-V-1 cells showed the overexpression of MDR-1 gene
, which is known as a main reason in changing the intracellular drug concentration.
10) found that a polymorphism in exon 26 (C3435T) of the MDR-1 gene was correlated with intestinal expression and in vivo activity of P-gp.
A 252-bp fragment of the MDR-1 gene (GenBank Accession No.
Therefore, genotyping of the C3435T polymorphism may provide a basis for treating patients more effectively with agents that are substrates of the MDR-1 gene