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mdr-1 gene

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mdr-1 gene
multi-drug resistance gene; normally responsible for maintaining the blood-brain barrier to certain drugs. A deletion mutation in this gene is responsible for the sensitivity to ivermectin observed in Collie dogs and related breeds.


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KB-V-1 cells showed the overexpression of MDR-1 gene, which is known as a main reason in changing the intracellular drug concentration.
In this study no significant correlation was found between the presence of the MDR-1 gene in the initial biopsy and the patient's clinical outcome.
The results further showed that Targretin prevented resistance and cross-resistance by suppressing the expression of the MDR-1 gene and the activity of the P-glycoprotein pump in NSCLC cells.
 
 
 
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