mdr-1 gene

mdr-1 gene

multi-drug resistance gene; normally responsible for maintaining the blood-brain barrier to certain drugs. A deletion mutation in this gene is responsible for the sensitivity to ivermectin observed in Collie dogs and related breeds.
References in periodicals archive ?
Variation in number of copies of Plasmodium vivax mdr-1 gene in 607 isolates from residents of and travelers from France to malaria-endemic areas, South America, Asia, and Africa, 1997-2009 Variable Residents Travelers No.
KB-V-1 cells showed the overexpression of MDR-1 gene, which is known as a main reason in changing the intracellular drug concentration.
10) found that a polymorphism in exon 26 (C3435T) of the MDR-1 gene was correlated with intestinal expression and in vivo activity of P-gp.
A 252-bp fragment of the MDR-1 gene (GenBank Accession No.
Therefore, genotyping of the C3435T polymorphism may provide a basis for treating patients more effectively with agents that are substrates of the MDR-1 gene product, e.