IL24

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IL24

A gene on chromosome 1q32 that encodes interleukin-24, a cytokine which may contribute to terminal cell differentiation. It has antiproliferative properties on melanoma cells. IL24 is also a popular, non-HUGO symbol for what is now designated IL17F, see there.
References in periodicals archive ?
Preclinical studies using lung cancer cells have demonstrated, for the first time, that MDA-7 protein binds to a critical cellular enzyme called PKR.
We have shown that INGN 241 potently kills pancreatic cancer cells and also identified a bystander effect whereby neighboring cancer cells are also killed by secreted MDA-7 protein.
The patent relates to treatment methods employing the mda-7 tumor suppressor gene.
The patent covers the methods by which introduction of the mda-7 gene into cancer cells induces apoptosis, or programmed cell death, regardless of the vector used to deliver the gene.
Structural analysis of the MDA-7 protein reveals that it is a novel member of the interleukin-10 (IL-10) family of cytokines and led to the classification of the mda-7 gene as IL-24.
announced that its mda-7 based cancer drug, INGN 241, demonstrated potent anti-angiogenic properties in a preclinical study recently presented during the annual meeting of the American Society of Gene Therapy.
INGN 241 supplies MDA-7 protein which induces cancer cell killing, or apoptosis, in many types of cancer.
announced today that eight abstracts which highlight Introgen's mda-7 based cancer drug, INGN 241 have been published in the 2003 Proceedings Online of the American Association for Cancer Research (AACR).
Finally, Introgen has developed methods to purify MDA-7 protein to 95 percent purity.
Fisher's laboratory discovered the mda-7 gene for which Introgen holds an exclusive license from the Corixa Corporation in all gene therapy applications.
director of research and development at Introgen commented, "We had previously discovered that the mda-7 gene was located within a cluster of cytokine genes and our bioinformatics analyses suggested that mda-7 might be a new cytokine.
We believe that loss of MDA-7 protein expression from tumor cells serves to 'release the brakes' on tumors, and allows conversion from non-invasive primary tumors to invasive and ultimately metastatic aggressive cancers," said Dr.