maximum tolerable dose

maximum tolerable dose

The highest dose of a substance that can be given without causing serious weight loss or other signs of toxicity.

maximum tolerable dose

The highest dose of a substance that can be given without causing serious weight loss or other signs of toxicity. See Maximum contaminant level.
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In Part 1, we are determining the maximum tolerable dose (MTD) of LB-100 administered alone; in Part 2, we are determining the MTD of LB-100 combined with the widely used anti-cancer drug, docetaxel, as the basis for designing studies of LB-100 plus docetaxel in Phase II trials in solid tumors.
Respondents stated that the most common sources of ambiguity were the definition of acceptable blood pressure values and the maximum tolerable dose of vasopressors.
Unfortunately, treatment with systemic chemotherapy comes at a cost: both bleomycin and doxorubicin have a maximum tolerable dose before long-term complications become evident.
Biological therapy was added to the regimen in patients who failed to achieve remission at the maximum tolerable dose of methotrexate.
In fact, when compared to placebo, ACE inhibitors used at maximum tolerable dose prevented death in patients with diabetic kidney disease (RR 0.
Phase Two: More patients are recruited - between 25 and 50 - and tests are done to see what effect the drug has and to establish the MTD - maximum tolerable dose - and compare its efficacy with current medication.
Phase I studies follow a dose-escalation regimen designed to determine the maximum tolerable dose (MTD).
The intended enrollment of 12 patients is being divided into four groups, three with increasing doses of ChronVac-C and the fourth at the maximum tolerable dose.
Kovach concluded, "The primary goal of our current Phase I trial is to determine the maximum tolerable dose (MTD) of LB-100 in combination with docetaxel and then to test to what extent LB-100 improves the efficacy of docetaxel against common solid tumors in Phase 2 trials.
Patients received a single-session dose escalation to estimate their maximum tolerable dose (MTD) followed by an 8-week open-label daily course of SLIT using a metered dosing device specifically designed for the trials.
KaloBios is conducting a Phase 1 dose escalation study of KB004 in hematologic malignancies seeking a maximum tolerable dose, and commenced the Phase 2 expansion portion of the study in early 2014.
The Phase I trial will evaluate the safety and maximum tolerable dose of sublingual-oral immunotherapy in patients with confirmed Timothy grass pollen allergy and history of at least one systemic reaction to subcutaneous immunotherapy.

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