maximum tolerable dose

maximum tolerable dose

The highest dose of a substance that can be given without causing serious weight loss or other signs of toxicity.

maximum tolerable dose

The highest dose of a substance that can be given without causing serious weight loss or other signs of toxicity. See Maximum contaminant level.
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We look forward to continuing this study to further identify the maximum tolerable dose of ADCT-301 and provide a preliminary assessment of its single-agent anti-tumor activity and toxicity profile.
This clinical trial will test the safety and maximum tolerable dose of LTI-01 in patients who have pneumonia-like symptoms with a build-up of non-draining fluid around their lungs.
The recommended starting dose is 300 mg daily in those without contraindications, with dose escalation daily as tolerated up to a maximum tolerable dose of 1,800 mg daily in two divided doses.
Respondents stated that the most common sources of ambiguity were the definition of acceptable blood pressure values and the maximum tolerable dose of vasopressors.
In cases where the drug side effects are intolerable due to which total removal of illness is not possible the patient should be provided maximum tolerable dose.
Unfortunately, treatment with systemic chemotherapy comes at a cost: both bleomycin and doxorubicin have a maximum tolerable dose before long-term complications become evident.
In fact, when compared to placebo, ACE inhibitors used at maximum tolerable dose prevented death in patients with diabetic kidney disease (RR 0.
Phase Two: More patients are recruited - between 25 and 50 - and tests are done to see what effect the drug has and to establish the MTD - maximum tolerable dose - and compare its efficacy with current medication.
Phase I studies follow a dose-escalation regimen designed to determine the maximum tolerable dose (MTD).
The intended enrollment of 12 patients is being divided into four groups, three with increasing doses of ChronVac-C and the fourth at the maximum tolerable dose.
With the impressive activity already observed at low doses, we look forward to continuing this study to further identify the maximum tolerable dose and provide a preliminary assessment of its single-agent anti-tumor activity and toxicity profile.
Biological therapy was added to the regimen in patients who failed to achieve remission at the maximum tolerable dose of methotrexate.

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