The patient was discharged on a maximal dose
of calcium channel blockers and nitrate.
In Phase 1, patients 10, 11, and 12 each received 10 lumbar and five cervical injections, of 100,000 cells each, which was far below the safe maximal dose
There were no safety issues and the cell infusions were well tolerated (with a maximal dose
of 246 million cells).
This is equivalent to the lower maximal dose
proposed by EMA for adolescents (i.
2]-agonists at doses up to and including the maximal dose
as stipulated on the WADA 2014 Prohibited List (WADA, 2014) on endurance exercise.
2) Doses in this study exceed the currently FDA-approved maximal dose
of 75 mg daily.
The maximal dose
of a drug and steady state are different in nonpregnant and pregnant patients, of course, because drug clearance is higher during pregnancy.
Martin et al reported a 55% 28 day survival in 57 patients receiving a mean (standard deviation) maximal dose
There should also be a maximal dose
that corresponds to the largest tolerated dose.
All the women in the study were asthmatics who required the maximal dose
of albuterol in order to control their asthma.
Subjects in the Phase Ia multiple ascending dose (MAD) segment of the study received 5 days of ACH-1625 up to a maximal dose
of 2000 mg per day.
6) In very small randomized trial of 20 patients with type 2 diabetes, adding 16 mg of candesartan to the maximal dose
of an ACE inhibitor decreased albuminuria an additional 28%.