maturity onset diabetes of the young type 4

maturity onset diabetes of the young type 4

An autosomal dominant endocrinopathy (OMIM:606392) of childhood to early adult onset, which is characterised by a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Molecular pathology
Defects in PDX1, which encodes a transcription activator that regulates tissue-specific expression of multiple genes, cause maturity onset diabetes of the young type 4.
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