maturity onset diabetes of the young type 2

maturity onset diabetes of the young type 2

An autosomal dominant endocrinopathy (OMIM:125851) of childhood to early adult onset, which is characterised by a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Molecular pathology
Caused by defects in GCK on chromosome 7p15.3-p15.1, which encodes a glucokinase that phosphorylates glucose, the first usual step in glucose metabolism.
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