maturity onset diabetes of the young


Also found in: Dictionary, Wikipedia.
Related to maturity onset diabetes of the young: maturity onset diabetes of the young type 2

maturity onset diabetes of the young

Any of a number  of dominantly inherited, monogenic defects of insulin secretion occurring at any age (most commonly types 2 and 3). MODYs do not include any forms of type-2 diabetes, and comprise 1–2% of those initially diagnosed with diabetes. Given that MODYs are autosomal dominant, those with the faulty gene have a 95% chance of developing MODY during their lifetimes. Diagnosing MODY is important as some forms do not need insulin and may do well with oral hypoglycaemic agents, and because other family members can be identified and their treatment modified if appropriate.

MODY susceptibility genes:
• MODY type 1—HNF4A 
• MODY type 2—GCK     
• MODY type 3—HNF1A
• MODY type 4—PDX1
• MODY type 5—HNF1B
• MODY type 6—NEUROD1
• MODY type 7—KLF11
• MODY type 8—CEL
• MODY type 9—PAX4
• MODY type 10—INS
• MODY type 11—BLK
References in periodicals archive ?
When she was first diagnosed as a diabetic in 1996 she had been told she had MODY, which is Maturity Onset Diabetes of the Young.
Mr Rheinberg also explained that Miss McNicholas had been diagnosed as suffering type two diabetes or maturity onset diabetes of the young (MODY).
Mr Rheinberg said Miss McNicholas was diagnosed with type two diabetes or maturity onset diabetes of the young.

Full browser ?