mature T-cell neoplasms

mature T-cell neoplasms

A group of neoplasms defined by the WHO classification (first published in 2001 and updated in 2008, which draws their parentage from the REAL (Revised European American Lymphoma) classification), which groups lymphomas by cell type (i.e., the normal cell type that most resembles the tumour) and defining phenotypic, molecular or cytogenetic characteristics.

Mature T cell neoplasms
▪ T-cell prolymphocytic leukaemia.
▪ T-cell large granular lymphocytic leukaemia.
▪ Adult T-cell leukaemia/lymphoma.
▪ Extranodal NK/T cell lymphoma, nasal type.
▪ Enteropathy-type T-cell lymphoma.
▪ Hepatosplenic T-cell lymphoma.
▪ Mycosis fungoides (Sezary syndrome).
▪ Primary cutaneous CD30-positive T-cell lymphoproliferative disorders.
▪ Primary cutaneous anaplastic large cell lymphoma.
▪ Lymphomatoid papulosis.
▪ Angioimmunoblastic T-cell lymphoma.
▪ Peripheral T-cell lymphoma, unspecified.
▪ Anaplastic large cell lymphoma.
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55,57,58) The WHO has divided the mature T-cell neoplasms into specifically defined entities.
Despite being an uncommon neoplasm, in just 25 years ALCL has emerged as a distinct entity and arguably the best characterized of the mature T-cell neoplasms.