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maturation arrest

   Also found in: Dictionary/thesaurus, Legal, Encyclopedia, Wikipedia 0.01 sec.
arrest /ar·rest/ (ah-rest´) cessation or stoppage, as of a function or a disease process.
cardiac arrest  sudden cessation of the pumping function of the heart with disappearance of arterial blood pressure, connoting either ventricular fibrillation or ventricular standstill.
developmental arrest  a temporary or permanent cessation of development.
epiphyseal arrest  premature interruption of longitudinal growth of bone by fusion of the epiphysis and diaphysis.
maturation arrest  interruption of the process of development, as of blood cells, before the final stage is reached.
sinus arrest  a pause in the normal cardiac rhythm due to a momentary failure of the sinus node to initiate an impulse, lasting for an interval that is not an exact multiple of the normal cardiac cycle.

maturation arrest
n.
The cessation of complete differentiation of cells at an immature stage.

arrest [ah-rest´]
sudden cessation or stoppage.
cardiac arrest see cardiac arrest.
epiphyseal arrest premature arrest of the longitudinal growth of bone due to fusion of the epiphysis and diaphysis.
maturation arrest interruption of the process of development, as of blood cells, before the final stage is reached.

arrest
sudden cessation or stoppage.

cardiac arrest
sudden and often unexpected stoppage of effective heart action. Either the periodic impulses which trigger the coordinated heart muscle contractions cease or ventricular fibrillation or flutter occurs in which the individual muscle fibers have a rapid irregular twitching.
epiphyseal arrest
premature arrest of the longitudinal growth of bone due to fusion of the epiphysis and diaphysis.
maturation arrest
interruption of the process of development, as of blood cells, before the final stage is reached.
sinoatrial arrest
a disturbance in cardiac conduction in which the sinoatrial node intermittently fails to generate an impulse. There are no P waves or PQRS-T complexes for at least twice the normal R-R interval. If the pauses are long enough, junctional or ventricular escape complexes may occur. Occurs most commonly in brachycephalic dogs, causing only minor clinical signs.

maturation
1. the stage or process of attaining maximal development. In biology, a process of cell division during which the number of chromosomes in the germ cell is reduced to one-half the number characteristic of the species.
2. the formation of pus.

maturation arrest
an interruption in the progressive development of erythrocytes, characterized by a bone marrow dominated by macrocytes and megaloblasts. Seen in anemias caused by deficiency of folic acid and vitamin B12.


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[11] Rather than retrodifferentiation or dedifferentiation, the process might be better described as blocked differentiation or a maturation arrest in stem cells that is controlled by regulation of the genome.
A differential count was performed for each bone marrow specimen to determine the degree of maturation arrest, as assessed morphologically, in patients with MDS compared with controls.
 
 
 
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