matrix metalloproteinase inhibitor


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matrix metalloproteinase inhibitor

An inhibitor of matrix metalloproteinases, which may be native (tissue inhibitors of metalloproteinase, or TIMPs) or synthetic. They are of interest to the pharmaceutical industry as potential therapeutic agents, as MMPs have been implicated in a vast array of human disorders, including arthritis, cancer and connective tissue diseases.

matrix metalloproteinase inhibitor

An agent that inhibits cancer cells by blocking their abilities to invade tissues, demand new blood supply, and metastasize.
See also: inhibitor
References in periodicals archive ?
BB-3644 is a second-generation matrix metalloproteinase inhibitor.
Marimastat, a matrix metalloproteinase inhibitor, is in Phase III development for the treatment of cancer; BB-3644, a follow-on to marimastat, is in Phase I development for cancer; BB-10153 has completed Phase I development for cardiovascular disease; BB-2827, a collagenase inhibitor for inflammation, is in Phase I development; and E21R, a modified GM-CSF, has completed Phase I development.
Its lead product, marimastat, a matrix metalloproteinase inhibitor, is in Phase III development for the treatment of cancer and has been licensed worldwide to Schering Plough Corporation except for Japan and the Far East where it has been licensed to Tanabe Seiyaku Co.
BB-2827 is a collagenase-selective matrix metalloproteinase inhibitor.
Matrix metalloproteinase inhibitors in rheumatic diseases.
Overall, Linder recommended using a formula that contains broad-spectrum UV protection, matrix metalloproteinase inhibitors (MMPi), antioxidants, retinoids, ascorbic acid and peptides to improve collagen and matrix protection and production.
Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases [Electronic version].

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