matrix metalloproteinase 8

matrix metalloproteinase 8

An enzyme encoded on chromosome 11q21-q22 which degrades collagens and other tissue substrates.

Cytokine inducers 
IL-1β, TNF-α.
 
Substrates
Collagens I, II, III, V, VII, VIII and X; gelatin; aggrecan; α1-AT; α1-ACHYM; α2-antiplasmin; fibronectin.
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