matrix metalloproteinase 7


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matrix metalloproteinase 7

A 19-kD enzyme encoded on chromosome 11q21-q22 which degrades fibronectin, gelatins and other matrix substrates.

Cytokine inducers 
BTC, EGF, FGF-a, FGF-b, FGF-9, FGF-10, hourG-β1, IL-1α, IL-1β, IL-4, IL-10, TGF-β1, TNF-α.
 
Substrates
Collagens IV and X; gelatin; aggrecan; decorin; proteoglycan link protein; fibronectin and laminin; insoluble fibronectin fibrils; entactin; large and small tenascin-C; osteonectin; β4 intergrin; elastin; casein; transferrin; MBP; α1-AT; GST-TNF/TNF peptide; plasminogen; MMP-1; MMP-2; MMP-9; MMP-9/TIMP-1 complex.
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