matrix metalloproteinase 14

matrix metalloproteinase 14

An enzyme encoded on chromosome 14q11-q12 which degrades extracellular matrix and other tissue substrates.

Substrates
Collagens I, II and III; casein, k-elastin, fibronectin, laminin, vitronectin and proteoglycans; large tenascin-C, entactin; α1-AT, α2M; GST-TNF; MMP-2; MMP-13.
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NASDAQ:DYAX) and Kadmon Corporation, LLC (Kadmon) announced today that they have entered into a strategic licensing agreement in which Kadmon has been granted an exclusive worldwide license for the development and commercialization of the fully human monoclonal antibody DX-2400, a potent and selective antibody inhibitor of matrix metalloproteinase 14 (MMP-14).

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