matrix metalloproteinase 13

matrix metalloproteinase 13

An enzyme encoded on chromosome 11q22.3 which degrades extracellular matrix and other tissue substrates.

Cytokine inducers
EGF, FGF-b, FGF-7, IGF-1, IL-1β, IL-6, IL-13, LIF, oncostatin M, PDGF, PDGF-BB, TGF-α, TGF-β1, TGF-β2, TNF-α.
 
Substrates
Collagens I, II and III, IV, IX, X and XIV; gelatin, α1-ACHYM and plasminogen activator inhibitor 2; aggrecan; perlecan; large tenascin-C and fibronectin; osteonectin; MMP-9.
References in periodicals archive ?
Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice," The Journal of Biological Chemistry, vol.
Loeser, "Stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes," Arthritis & Rheumatology, vol.
Bosserhoff, "Activating enhancer binding protein 2 epsilon (AP-2[epsilon])-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development," Arthritis Research and Therapy, vol.

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