matrix bias

matrix bias

Any deviation in values for a particular analyte which was introduced by a matrix effect. Matrix bias impacts on proficiency testing values and lab results in general.
References in periodicals archive ?
A matrix effect or a matrix bias can be caused by differences in sample matrix between the reference material and the native clinical samples.
A statistically significant difference indicates the presence of a matrix bias (i.
Table 4 shows the matrix bias correction factor of each lyophilized material for the different method groups.
All matrix bias correction factors were calculated with the peer group means, but we tried also to calculate the factors by using single laboratory data of the same peer group.
The matrix-adjusted target values can be an acceptable compromise that allows the utilization of the lyophilized sera provided that two important limitations are adequately considered: (a) the matrix bias correction factor can be calculated only for well-defined analytical systems; (b) the serum pools used in generating the algebraic correction are the same as normal fresh serum specimens.