matrilysin

matrix metalloproteinase 7

A 19-kD enzyme encoded on chromosome 11q21-q22 which degrades fibronectin, gelatins and other matrix substrates.

Cytokine inducers 
BTC, EGF, FGF-a, FGF-b, FGF-9, FGF-10, hourG-β1, IL-1α, IL-1β, IL-4, IL-10, TGF-β1, TNF-α.
 
Substrates
Collagens IV and X; gelatin; aggrecan; decorin; proteoglycan link protein; fibronectin and laminin; insoluble fibronectin fibrils; entactin; large and small tenascin-C; osteonectin; β4 intergrin; elastin; casein; transferrin; MBP; α1-AT; GST-TNF/TNF peptide; plasminogen; MMP-1; MMP-2; MMP-9; MMP-9/TIMP-1 complex.

matrilysin

A member of the matrix metalloproteinase enzyme family that is expressed by many tumor cells and plays a part in tissue invasion and metastasis.
References in periodicals archive ?
A study involving 156 patients, who underwent radical nephrectomy due to RCC, was focused on the assessment of matrilysin 1 in relation to the aggressiveness and malignancy of this tumour.
Tissue inhibitor of metalloproteinase-1 moderates airway reepithelialization by regulating matrilysin activity.
Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans," Proceedings of the National Academy of Sciences of the United States of America, vol.
Collagenases, gelatinases, stromelysin-3, matrilysin, MT1-MMP [99], and stromelysin-1 [100] are considered the most closely associated to the invasive phenotype.
Up-Regulated Expression Of Matrilysin And Neutrophil Collagenase in Human Herniated Discs.
Matrilysin overexpression in MCF-7 cells enhances cellular invasiveness and pro-gelatinase activation.
The in vivo expression of the collagenolytic matrix metalloproteinases (MMP-2,-8,-13, and -14) and matrilysin (MMP-7) in adult and localized juvenile periodontitis.
Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense.
56) Mouse intestinal [alpha]-defensin is secreted as an inactive form and activated through cleavage of the precursor by matrilysin.
Zuo et al (4) previously reported the overexpression of matrix metalloproteinase 7 (MMP-7), also called matrilysin 1, by oligonucleotide microarrays and immunohistochemistry in the fibrotic lung tissues of patients with IPF.
Regulation of intestinal alphadefensin activation by the metalloproteinase matrilysin in innate host defense.
inflammation (elastases, cathepsins, matrix metalloproteinases, and phospholipases); cancer (protein typrosine kinase, matrilysin, collagenase IV); acne (transglutaminase).