Up-Regulated Expression Of Matrilysin
And Neutrophil Collagenase in Human Herniated Discs.
overexpression in MCF-7 cells enhances cellular invasiveness and pro-gelatinase activation.
Zuo et al (4) previously reported the overexpression of matrix metalloproteinase 7 (MMP-7), also called matrilysin
1, by oligonucleotide microarrays and immunohistochemistry in the fibrotic lung tissues of patients with IPF.
Other MMPs, such as matrilysin
and interstitial collagenase, are believed to be involved in normal adult biological processes, including collagen turnover and endometrial cycling.
inflammation (elastases, cathepsins, matrix metalloproteinases, and phospholipases); cancer (protein typrosine kinase, matrilysin
, collagenase IV); acne (transglutaminase).
2-4) Secreted-type MMPs can be classified into 6 subgroups according to their substrate specificity and structural differences (2): (1) collagenases, including tissue collagenase (MMP1), neutrophil collagenase (MMP8), and collagenase 3 (MMP13); (2) gelatinases, such as gelatinase A (MMP2) and gelatinase B (MMP9); (3) stromelysins, including stromelysin 1 (MMP3) and stromelysin 2 (MMP-10); (4) matrilysins
, such as matrilysin
1 (MMP7) and matrilysin
2 (MMP26); (5) furin-activated MMPs, including stromelysin 3 (MMP-13) and epilysin (MMP 28); and (6) other MMPs such as metalloelastase (MMP12), MMP19, enamelysin (MMP-20), MMP21, and MMP-27.
is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1-antitrypsin.
Association of trypsin expression with tumour progression and matrilysin
expression in human colorectal cancer.
(matrix metal loproteinase-7): a new promising drug target in cancer and inflammation?
(MMP7) is a protease with broad substrate specificity, being able to degrade elastin, proteoglycans, fibronectin, and type IV collagen.
These MMPs are divided into five subgroups according to their substrate specificity and structural similarities: Collagenases, stromelysins, gelatinases, matrilysins
and membrane-type MMPs (Mook et al.
Commonly reported MMPs include collagenases, gelatinases, matrilysins