3 shows a dose-response comparative study with sodium cromoglycate, a classical mast cell stabilizer
These include cases of chronic allergic conjunctivitis unresponsive to routine treatments (OT, November 12 2010), advanced presentations of VKC (again unresponsive to mast cell stabilizer
treatments), ocular rosacea, episcleritis (of various aetiologies) and, of course, intraocular inflammations of the anterior segment associated with the iris and anterior uvea.
Pipeline candidates fall under major therapeutic classes such as histamine antagonist and mast cell stabilizers
, immune system modulators, glucocorticoid receptor antagonists and Leutocyte elastate inhibitors.
Indeed, the idea for use of a mast cell stabilizer is to try to reduce or even prevent the mast cells from discharging histamine and prostaglandins (degranulation) following their IgE-mediated activation by allergens.
They can also access the dual acting drugs, ie, ketotifen and olopatadine, as well as selective antihistamines (eg, azelastine and emedastine), all of which can be used in a similar manner to a mast cell stabilizer with certain caveats.
Some practitioners might advocate a conservative approach for daily lens wearers with allergies, which would entail Instillation of eye drops (either a decongestant, mast cell stabilizer or a topical ocular antihistamine) 5 to 10 minutes prior to morning lens insertion.
Several topically used products from anti-histamines and mast cell stabilizers
classes and use of topical corticosteroids and NSAID (in cases of chronic conditions) are currently managed for the treatment of ocular allergies with good efficacy and safety profiles.
Current treatments for allergic conjunctivitis include antihistamines, mast cell stabilizers
Mast cell stabilizers
, such as cromolyn sodium, provide a protective barrier that shields mast cells from offending allergens, preventing these symptoms.
Comprehensive qualitative and quantitative analysis is provided for all six therapeutic classes: beta agonists, inhaled corticosteroids, anticholinergics, leukotriene inhibitors, mast cell stabilizers
, and xanthines.