mast cell stabilizers


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Related to mast cell stabilizers: leukotriene modifiers

mast cell stabilizers

Prophylactic drugs used to treat allergic conjunctivitis, vernal conjunctivitis, giant pupillary conjunctivitis, superior limbic keratoconjunctivitis. They act by stabilizing the membranes of mast cells thus preventing the release of histamine. Common agents are sodium cromoglicate (cromolyn sodium), lodoxamide, nedocromil sodium, olopatadine hydrochloride and pemirolast potassium. See antihistamine; hypersensitivity.
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Table 1: Distribution of patients according to sex Number of Percentage Sex Patients (%) Male 60 60% Female 40 40% Total 100 100 Table 2: Distribution of patients according to age Age of the Number of Percentage Patient Patients (%) 10-20 15 15% 21-30 40 40% 31-40 15 15% 41-50 25 25% 51-60 5 5% Table 3: Results Number RESULTS (Percentage) Treatment of Given Patients Good Satisfactory Poor Antihistamines + 25 50% 25% 25% Nasal Decongestants Antihistamines + 25 50% 30% 20% Nasal Decongestants + Corticosteroid Sprays Antihistamines+ 25 50% 35% 15% Nasal Decongestants + Mast cell stabilizers Specific Immunotherapy+ 25 80% 15% 5% Avoidance
Because of study heterogeneity, a random-effects model was used and showed that topical mast cell stabilizers relieved symptoms (ocular itching, burning, and lacrimation) 4.
3 shows a dose-response comparative study with sodium cromoglycate, a classical mast cell stabilizer.
Combination mast cell stabilizers and antihistamines, which combine mechanisms of both antihistaminic and mast cell stabilization in a single drug, are the most recently developed drugs for topical treatment of ocular allergies.
These include cases of chronic allergic conjunctivitis unresponsive to routine treatments (OT, November 12 2010), advanced presentations of VKC (again unresponsive to mast cell stabilizer treatments), ocular rosacea, episcleritis (of various aetiologies) and, of course, intraocular inflammations of the anterior segment associated with the iris and anterior uvea.
While the market remains well served by histamine receptors and mast cell stabilizers, the newer candidates will have substantial scope for growth and profitability.
Indeed, the idea for use of a mast cell stabilizer is to try to reduce or even prevent the mast cells from discharging histamine and prostaglandins (degranulation) following their IgE-mediated activation by allergens.
For the analysis, the researchers selected parents of children aged 17 years and younger who had persistent symptoms according to national asthma guidelines and/or used preventive asthma medications (defined as inhaled corticosteroids, mast cell stabilizers, theophylline derivatives, leukotriene modifiers, and combined corticosteroids and longacting [[beta].
For the analysis, the researchers selected parents of children aged 17 years and younger who had persistent symptoms according to national asthma guidelines and/or used preventive asthma medications (the latter defined as inhaled corticosteroids, mast cell stabilizers, theophylline derivatives, leukotriene modifiers, and combined corticosteroids and long-acting [[beta].
Anti-inflammatory medications, most notably corticosteroids, and mast cell stabilizers (leukotriene inhibitors) are the first-line drugs of current treatment.
The global allergic conjunctivitis market in 2009 primarily comprised of drug classes which included anti-histamines, mast cell stabilizers, dual action agents, non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroid products.