maspin


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maspin

A 42-kD tumour suppressor protein of the serpin superfamily, encoded by SERPINB5 on chromosome 18q21.3. Despite its name, maspin (mammary serine protease inhibitor) has no serine protease inhibitory activity.

Normal expression
Various epithelial cells.

Abnormal expression
Downregulated in breast, prostate and colorectal carcinomas; upregulated in pancreatic, gastric and ovarian cancers.
References in periodicals archive ?
Role for DNA methylation in the control of cell type specific maspin expression.
20) When the stroma associated with papillary lesions are sclerotic or exuberant, nuclear stains, such as p63 and maspin, should be included in a myoepithelial marker panel to avoid cross-reactivity with myofibroblasts within the sclerotic stroma.
But researchers have discovered that breast cancer cells which spread do not produce a protein called maspin.
However, researchers at Northumbria University have discovered that breast cancer cells which spread do not produce a protein called maspin.
Ann Chambers, and colleagues discovered that maspin, a cellular protein, could reduce the growth and spread of cancer cells, but only when it is in the nucleus.
Expression analysis of maspin in invasive ductal carcinorna of breast and modulation of its expression by curcumin in breast cancer cell lines.
Their research goal was to test whether maspin is sufficient to drive mesenchymal-to-epithelial transition, a process found in some cancer cells that have undergone micro-metastasis but have since reverted back to a dormant state.
Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression.
FRIDAY Disco queen: Ms Spears is still maspin, clutching a CD after a few days on the razzle dazzle' Oops.
After searching through thousands of candidates, the researchers focused on Maspin, a tumor-suppressing gene that's active in the fetal cells of a placenta but not typically in a mother's cells.
The gene encoding maspin has been identified by Dana-Farber to inhibit tumor cell growth, invasion, and metastasis in breast and prostate cancer.
2, CK [cytokeratin] 7, CK20, CK17, CK19, MUC1, MUC2, MUC4, MUC5AC, MUC6, p53, DPC4/ SMAD4, CDX2, pVHL [von Hippel-Lindau tumor suppressor gene protein], S100P, IMP-3 [insulin-like growth factor 2 messenger RNA binding protein 3], maspin, mesothelin, claudin 4, claudin 18, annexin A8, fascin, PSCA [prostate stem cell antigen], MOC31, CEA [carcinoembryonic antigen], and CA19-9 [cancer antigen 19-9]) in the diagnosis of ductal adenocarcinoma of the pancreas by using 60 cases of pancreatic DAC on routine and tissue microarray (TMA) sections.