maspin


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maspin

A 42-kD tumour suppressor protein of the serpin superfamily, encoded by SERPINB5 on chromosome 18q21.3. Despite its name, maspin (mammary serine protease inhibitor) has no serine protease inhibitory activity.

Normal expression
Various epithelial cells.

Abnormal expression
Downregulated in breast, prostate and colorectal carcinomas; upregulated in pancreatic, gastric and ovarian cancers.
References in periodicals archive ?
3) To our knowledge, S100P, insulin-like growth factor 2 messenger RNA-binding protein-3 (IMP3), maspin, von HippelLindau gene product (pVHL), SMAD4, CK17, and MUC5AC appear to be better investigated (Table 6), and will be briefly discussed here.
Maspin, p53, p63, and Ki- 67 in epithelial lesions of the tongue: from hyperplasia through dysplasia to carcinoma.
One of the possible mechanisms by which CLIC1 mediates invasion is by regulating maspin (tumor suppressor), matrix metalloproteinases [172], annexin A7, and gelsolin [173].
Moreover, maspin is an epithelial specific 42 kDa that acts as an endogenous inhibitor of histone deacetylase (HDAC1) [19,20].
36] found frequent positivity for SMA and CK14, as well as immunoreactivity for S100 protein, p63, maspin and p-cadherin.
miRNAs Blanco asociado Funcion del miRNA en metastasis de tumor miR-10b HOXD10 Promotor miR-21 PTEN, PDCD4, TPM1, Maspin Promotor miR-373 CD44, LATS2 Promotor miR-520c CD44 Promotor miR-155 RhoA Promotor Let-7 Ras, HMGA2 Represor miR-335 SOX4, TNC Represor miR-126 Crk, IRS-1 Represor miR-146a ROCK1 Represor miR-101 EZH2 Represor Familia miR-200 ZEB1, ZEB2 Represor
Our studies indicate that in mammary epithelial cells Maspin is deposited in the extracellular matrix, and functions as a positional cue in directing CatD-mediated ECM degradation [83].
Detection of the placental epigenetic signature of the maspin gene In maternal plasma.
Maspin, p53, and Ki-67 in epithelial lesions of the tongue: from hyperplasia to dysplasia to carcinoma.
But researchers have discovered that breast cancer cells which spread do not produce a protein called maspin.
However, researchers at Northumbria University have discovered that breast cancer cells which spread do not produce a protein called maspin.
Ann Chambers, and colleagues discovered that maspin, a cellular protein, could reduce the growth and spread of cancer cells, but only when it is in the nucleus.