marrow fibrosis

marrow fibrosis

A general term for the presence of increased reticulin in the bone marrow, which causes spindling of the marrow cells.

Aetiology
Systemic mastocytosis, cancer (carcinoma, lymphoma, myeloma, myeloproliferative disorders), HIV.
References in periodicals archive ?
Assessments include measuring changes in spleen volume, patient reported total symptom scores, mutant allele burden, inflammatory cytokines as well as bone marrow fibrosis over the course of the treatment period.
2 The characteristic signs of this disease include bone marrow fibrosis, anaemia, splenomegaly, bone pain, night sweats and tear drop cells in the blood film.
Progression of bone marrow fibrosis in patients with essential thrombocythemia and polycythemia vera during anagrelide treatment.
For bone marrow fibrosis, the difference was not statistically significant (p>0.
Al-Ibrahimi conducted successful bone marrow transplants on 12 Bahraini children in Jordan over the past years -- 2 cases of leukemia, 5 cases of Thalassemia, 1 case of bone marrow failure syndrome, 1 case of Bone marrow fibrosis, 1 case of Gideak Hakashy Syndrome and one case of Autologous bone marrow transplant.
The association between renal impairment, low 25(OH)-vitamin D, anemia, marrow fibrosis, severe osteoporosis, fibrocystic osteitis, high level of alkaline phosphatase and considerable volume of the parathyroid adenoma suggested a long neglected primary hyperparathyroidism and were considerable risk factors for a postoperative hungry bone syndrome.
Subtle focal intrasinusoidal collections of the cells, active bone remodelling and bone marrow fibrosis were also noted in these subcortical areas.
One was a known and treated case of CML with marrow fibrosis.
In summary, the MPNs are involved with one or more of the following features: overproduction of one or more cell lines, hypercellular marrow or bone marrow fibrosis, cytogenetic abnormalities, point mutations, extramedullary hematopoiesis, hemorrhagic bleeding and or thrombosis and can transform into an acute leukemia.
In addition, increased marrow fibrosis and vascularity are common histologic features of both.
The histologic features are marrow fibrosis with scattered mononuclear cells (figure 2).