marked atypia

marked atypia

adjective A term used by pathologists for an array of often preneoplastic cytologic or histologic changes, which may fall short of criteria used to define dysplasia or early cancer.
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The nuclei show moderate to marked atypia, which includes marked variation of nuclear sizes and shapes and hyperchromasia.
Lack of vasculature, inflammatory infiltrates, and the presence of marked atypia and mitoses ruled out inflammatory fibroid polyps.
Alternating fascicles of spindle cells with marked atypia and mitosis are part of the usual morphological picture shared by both leiomyosarcoma and sarcomatoid RCC.
i) Clear cell adenocarcinoma (CCA): CCA usually occurs in women; it lacks clinical characteristics of adenoma; CCAs tend to be very large tumours; microscopically CCAs exhibit mostly clear cells; there is marked atypia in CCAs; there is muscularis propria invasion in CCA; there is additionally high mitotic rate in CCA; there is necrosis in CCA; there is high Ki-67 percentage in CCA; in CCA, usually PAX2 is negative (even though distinction is usually made upon morphologic grounds); CCA exhibits strong staining with p63 [22-24].
Because marked atypia that is never associated with classical IDH was observed on a cytologic basis, inclusion of these cases in the AIDH group was considered more appropriate.
Pathologists were required to differentiate between subtle degrees of mild, moderate, or marked atypia.
3-cm lesion was a villous adenoma with marked atypia, and the 3.
C, Marked atypia with multinucleation alongside gaps along alveoli of residual type 1 cells (hematoxylin-eosin, original magnifications X10 [A], X20 [B], and X40 [C]).
In this scenario, high-power examination discloses more typical features of serous carcinoma including ragged luminal borders, marked atypia with pleomorphism, numerous mitotic figures, and single-cell apoptosis, all of which are typically absent in well-differentiated endometrioid carcinoma.
While mild to moderate atypia is common, marked atypia and marked, severe pleomorphism have not been reported.
However, Thomas et al (7) found marked atypia with bizarre hyperchromatic nuclei and multinucleated giant cells in their AL case.