marked atypia

marked atypia

adjective A term used by pathologists for an array of often preneoplastic cytologic or histologic changes, which may fall short of criteria used to define dysplasia or early cancer.
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Alternating fascicles of spindle cells with marked atypia and mitosis are part of the usual morphological picture shared by both leiomyosarcoma and sarcomatoid RCC.
Pathologists were required to differentiate between subtle degrees of mild, moderate, or marked atypia.
Case 23 showed marked atypia with numerous multinucleated neoplastic cells; case 30 had evidence of perineural neoplastic involvement.