margin of safety


Also found in: Dictionary, Thesaurus, Legal, Financial, Acronyms, Encyclopedia, Wikipedia.

margin

 [mahr´jin]
an edge or border.
gingival margin gum margin.
gum margin the border of the gingiva surrounding, but unattached to, the substance of the teeth.
margin of safety a calculation that takes the highest animal no observed adverse effect level and estimates a maximum safe level of exposure for humans. It is now generally superseded by the reference dose.

mar·gin of safe·ty

the range between the minimal therapeutic dose and the minimal toxic dose of a drug.

margin of safety

an index of a drug's effectiveness and safety. It is calculated as the amount of drug that is lethal to 1% of animals (LD1) divided by the amount of drug that causes a beneficial effect in 99% of the animals (ED99). See also dose-response relationship.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The area between the minimal therapeutic dose and the minimal toxic dose of a drug.
Synonym(s): safety margin.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The gap (i.e., range) between the minimal therapeutic dose of a drug and its minimal toxic dose.
References in periodicals archive ?
Under California law, CCRI's supporters must submit the signatures of just under 700,000 registered voters to put it on the ballot, with a margin of safety above that number to make up for the inevitable invalid signatures.
Previously, policymakers had thought the current ozone standard provided a margin of safety even to those considered at increased risk, including people with emphysema, asthma and other chronic respiratory problems.
This is another important milestone for Talecris Biotherapeutics, and particularly for our outstanding pathogen safety team, in demonstrating our relentless efforts to produce protein therapies with the highest possible margin of safety," said Steve Petteway, Ph.
A second study conducted by Kerin, suggests the Essure procedure can be performed on women suffering from serious health conditions with a high margin of safety eliminating the risk of complications that commonly follow laparoscopic tubal ligation carried out under general anesthesia.
On-site transformer monitoring is helping them watch their transformers more closely, operate them with a greater margin of safety, and manage them to minimize the costs of repairing or replacing these valuable assets.
3 million provides bondholders a limited margin of safety over the short-term.
While financial commitments are currently being met, the rating indicates that significant credit risk is present with a limited margin of safety remaining and capacity for continued payment is contingent upon a sustained, favorable business and economic environment.
If successful, the Hemopurifier to treat cancer will make it possible to provide surgical interventions in cases where surgery is not presently considered, and will add a significant margin of safety in cases where surgery is considered a viable treatment option.
has this to say: "His organization skills and medical experience will be greatly appreciated and although we hope the season goes without accident, the risk is always there and to have an experienced EMT who is also a diver provides a real increased safety factor, we will be working where medical assistance may take several hours to arrive on the scene if there is an accident, and with Luke being there it will just give the crew a larger margin of safety.