margin of safety


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margin

 [mahr´jin]
an edge or border.
gingival margin gum margin.
gum margin the border of the gingiva surrounding, but unattached to, the substance of the teeth.
margin of safety a calculation that takes the highest animal no observed adverse effect level and estimates a maximum safe level of exposure for humans. It is now generally superseded by the reference dose.

mar·gin of safe·ty

the range between the minimal therapeutic dose and the minimal toxic dose of a drug.

margin of safety

an index of a drug's effectiveness and safety. It is calculated as the amount of drug that is lethal to 1% of animals (LD1) divided by the amount of drug that causes a beneficial effect in 99% of the animals (ED99). See also dose-response relationship.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The area between the minimal therapeutic dose and the minimal toxic dose of a drug.
Synonym(s): safety margin.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The gap (i.e., range) between the minimal therapeutic dose of a drug and its minimal toxic dose.
References in periodicals archive ?
Yet we should see a definite increase in the margin of safety over time as we improve sales and grow the business.
Using the concept of the margin of safety when choosing a tracheobronchial (double-lumen) tube may help with efficient and efficacious placement of the tube.
The EPA leaves a minimum of a tenfold margin of safety to account for differences between children and adults, Taylor said, so ``it's well within EPA's margin of safety.
Based on what we've been told by the EPA, the reassessment will show that the margin of safety is probably narrower than the agency would like.
S&P's CreditWeek, published yesterday, cites the specialty bond insurer's "very strong capital adequacy," as evidenced by a margin of safety in the 1.
In some cases, we're really pushing the margin of safety.
The scientists also suggested that other types of radiation, such as beta particles, might provide a greater margin of safety for treated vessels, nearby healthy tissue, and operating-room staff.
July 15 /PRNewswire/ -- A little tool, smaller than a key, provides an important margin of safety to anyone outdoors in the event they are bitten by a tick, according to Richard Gadd.
Financial commitments are currently being met, but a limited margin of safety remains.